Autoinflammatory Reaction in Dogs Treated for Cancer via G6PD Inhibition
Glucose-6-phosphate dehydrogenase (G6PD) is an oncoprotein that is overexpressed in cancer cells to provide the NADPH required for their increased anabolism. NADPH, sourced from G6PD fuels nucleotide biosynthesis, maintains redox potential of thioredoxin and glutathione and drives the mevalonate pat...
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| Format: | Article |
| Language: | English |
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Hindawi Limited
2017-01-01
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| Series: | Case Reports in Veterinary Medicine |
| Online Access: | http://dx.doi.org/10.1155/2017/4275305 |