REGULATORY-ADAPTIVE STATE IN EVALUATION OF BISOPROLOL AND NEBIVOLOL THERAPY EFFECTIVENESS FOR VENTRICULAR ARRHYTHMIA

• Main Authors: I. Z. Shubitidze, V. G. Tregubov, S. G. Kanorskii, V. M. Pokrovsky
• Format: Article
• Language: Russian
• Published: «SILICEA-POLIGRAF» LLC 2016-12-01
• Series: Кардиоваскулярная терапия и профилактика
• Subjects: regulatory-adaptive state; ventricular cardiac arrhythmias; bisoprolol; nebivolol
• Online Access: https://cardiovascular.elpub.ru/jour/article/view/512
• ISSN: 1728-8800; 2619-0125

Aim. To compare  efficacy  of bisoprolol  and  nebivolol treatment   in ventricular arrhythmias patients (VA) and arterial hypertension (AH) and/ or  ischemic  heart  disease   (IHD) taken  its  influence  on  regulatoryadaptive state (RAS).Material and methods. Totally, 60 patients  participated  with VA  of Lown I-IV grades,  Bigger II-III grades,  at the background  of AH II-III stage  and/or  IHD, who were randomized  to 2 groups  of treatment: bisoprolol 6,5±1,8 mg daily or nebivolol 6,5±2,1 mg daily. As combination  therapy,  lisinopril was  used   12,3±4,0  mg  daily and 13,7±4,5   mg/daily,  acetylsalicylic  acid  92,3±18,8   mg/daily  and 92,9±18,2 mg/daily, atorvastatin 16,3±4,8 mg/daily and 16,5±4,7 mg daily together  with bisprolol or nebivolol, respectively. At baseline and in 6 months of therapy we performed: quantitative RAS assessment via the test of cardio-respiratory  synchronicity, echocardiography, triplex scanning of brachocephalic  arteries,  tredmill, six minute walking test, 24-hour blood pressure monitoring and ECG monitoring, self-assessed life quality.Results. Both  regimens  of  combination  therapy  comparably  same improved structural and functional state  of the heart, decreased blood pressure, effectively suppressed ventricular arrhythmia. However, only nebvolol positively influenced RAS, better improved exercise tolerance and improved life quality.Conclusion. In VA patients with AH of II-III stages  and/or IHD, usage of nebivolol, comparing  to bisoprolol, as  combination therapy,  might be more preferrable due to positive influence on RAS.