Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease
The adipocyte-secreted protein adiponectin (APN) has several protective functions in the peripheral tissues including insulin sensitizing, anti-inflammatory and anti-oxidative effects that may benefit neurodegenerative diseases such as Alzheimer’s disease (AD). In addition, dysregulation of cerebral...
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MDPI AG
2017-03-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | http://www.mdpi.com/1422-0067/18/3/592 |
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doaj-6314793058ca4640aa3257e80745c9d72020-11-25T01:08:00ZengMDPI AGInternational Journal of Molecular Sciences1422-00672017-03-0118359210.3390/ijms18030592ijms18030592Potential Neuroprotective Effects of Adiponectin in Alzheimer’s DiseaseRoy Chun-Laam Ng0Koon-Ho Chan1Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaDepartment of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, ChinaThe adipocyte-secreted protein adiponectin (APN) has several protective functions in the peripheral tissues including insulin sensitizing, anti-inflammatory and anti-oxidative effects that may benefit neurodegenerative diseases such as Alzheimer’s disease (AD). In addition, dysregulation of cerebral insulin sensitivities and signaling activities have been implicated in AD. Emerging insights into the mechanistic roles of adiponectin and AD highlight the potential therapeutic effects for AD through insulin signaling.http://www.mdpi.com/1422-0067/18/3/592adiponectinAlzheimer’s diseasecognitive impairmentsAmyloid-β |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Roy Chun-Laam Ng Koon-Ho Chan |
| spellingShingle |
Roy Chun-Laam Ng Koon-Ho Chan Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease International Journal of Molecular Sciences adiponectin Alzheimer’s disease cognitive impairments Amyloid-β |
| author_facet |
Roy Chun-Laam Ng Koon-Ho Chan |
| author_sort |
Roy Chun-Laam Ng |
| title |
Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease |
| title_short |
Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease |
| title_full |
Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease |
| title_fullStr |
Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease |
| title_full_unstemmed |
Potential Neuroprotective Effects of Adiponectin in Alzheimer’s Disease |
| title_sort |
potential neuroprotective effects of adiponectin in alzheimer’s disease |
| publisher |
MDPI AG |
| series |
International Journal of Molecular Sciences |
| issn |
1422-0067 |
| publishDate |
2017-03-01 |
| description |
The adipocyte-secreted protein adiponectin (APN) has several protective functions in the peripheral tissues including insulin sensitizing, anti-inflammatory and anti-oxidative effects that may benefit neurodegenerative diseases such as Alzheimer’s disease (AD). In addition, dysregulation of cerebral insulin sensitivities and signaling activities have been implicated in AD. Emerging insights into the mechanistic roles of adiponectin and AD highlight the potential therapeutic effects for AD through insulin signaling. |
| topic |
adiponectin Alzheimer’s disease cognitive impairments Amyloid-β |
| url |
http://www.mdpi.com/1422-0067/18/3/592 |
| work_keys_str_mv |
AT roychunlaamng potentialneuroprotectiveeffectsofadiponectininalzheimersdisease AT koonhochan potentialneuroprotectiveeffectsofadiponectininalzheimersdisease |
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