Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process

An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alcoholic ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl...

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Main Authors:	Chenkai Meng, Haolin Niu, Juehan Ning, Wengang Wu, Jun Yi
Format:	Article
Language:	English
Published:	MDPI AG 2020-01-01
Series:	Molecules
Subjects:	deprotection nickel chain walking phenol alcohol
Online Access:	https://www.mdpi.com/1420-3049/25/3/602

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record_format	Article
spelling	doaj-6312a8bdd06141c6b33d36e216930d4c2020-11-25T01:47:08ZengMDPI AGMolecules1420-30492020-01-0125360210.3390/molecules25030602molecules25030602Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking ProcessChenkai Meng0Haolin Niu1Juehan Ning2Wengang Wu3Jun Yi4Jiangsu Laboratory of Advanced Functional Material, School of Materials Engineering, Changshu Institute of Technology, Changshu 215500, ChinaJiangsu Laboratory of Advanced Functional Material, School of Materials Engineering, Changshu Institute of Technology, Changshu 215500, ChinaJiangsu Laboratory of Advanced Functional Material, School of Materials Engineering, Changshu Institute of Technology, Changshu 215500, ChinaJiangsu Laboratory of Advanced Functional Material, School of Materials Engineering, Changshu Institute of Technology, Changshu 215500, ChinaJiangsu Laboratory of Advanced Functional Material, School of Materials Engineering, Changshu Institute of Technology, Changshu 215500, ChinaAn efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alcoholic ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl group. The new reaction brings the homoallyl group into a start of new type of protecting group.https://www.mdpi.com/1420-3049/25/3/602deprotectionnickelchain walkingphenolalcohol
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Chenkai Meng Haolin Niu Juehan Ning Wengang Wu Jun Yi
spellingShingle	Chenkai Meng Haolin Niu Juehan Ning Wengang Wu Jun Yi Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process Molecules deprotection nickel chain walking phenol alcohol
author_facet	Chenkai Meng Haolin Niu Juehan Ning Wengang Wu Jun Yi
author_sort	Chenkai Meng
title	Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process
title_short	Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process
title_full	Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process
title_fullStr	Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process
title_full_unstemmed	Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process
title_sort	nickel-catalyzed removal of alkene protecting group of phenols, alcohols via chain walking process
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2020-01-01
description	An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alcoholic ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl group. The new reaction brings the homoallyl group into a start of new type of protecting group.
topic	deprotection nickel chain walking phenol alcohol
url	https://www.mdpi.com/1420-3049/25/3/602
work_keys_str_mv	AT chenkaimeng nickelcatalyzedremovalofalkeneprotectinggroupofphenolsalcoholsviachainwalkingprocess AT haolinniu nickelcatalyzedremovalofalkeneprotectinggroupofphenolsalcoholsviachainwalkingprocess AT juehanning nickelcatalyzedremovalofalkeneprotectinggroupofphenolsalcoholsviachainwalkingprocess AT wengangwu nickelcatalyzedremovalofalkeneprotectinggroupofphenolsalcoholsviachainwalkingprocess AT junyi nickelcatalyzedremovalofalkeneprotectinggroupofphenolsalcoholsviachainwalkingprocess
_version_	1725015956767375360

Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process

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