Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process

Nickel-Catalyzed Removal of Alkene Protecting Group of Phenols, Alcohols via Chain Walking Process

An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alcoholic ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl...

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Bibliographic Details
Main Authors: Chenkai Meng, Haolin Niu, Juehan Ning, Wengang Wu, Jun Yi
Format: Article
Language:English
Published: MDPI AG 2020-01-01
Series:Molecules
Subjects:
deprotection
nickel
chain walking
phenol
alcohol
Online Access:https://www.mdpi.com/1420-3049/25/3/602
Description
Summary:An efficient nickel-catalyzed removal of alkene protection group under mild condition with high functional group tolerance through chain walking process has been established. Not only phenolic ethers, but also alcoholic ethers can be tolerated with the retention of stereocenter adjacent to hydroxyl group. The new reaction brings the homoallyl group into a start of new type of protecting group.
ISSN:1420-3049

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