Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor

Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor

Plexiform fibrohistiocytic tumor (PFT) is a rare mesenchymal neoplasm of intermediate malignant potential with a high local recurrence rate. In this report, we describe a case of PFT on the ear, which showed a dense deposition of periostin (POSTN) in the stromal areas of the tumor. In addition, dens...

Full description

Bibliographic Details
Main Authors: Kosuke Shido, Taku Fujimura, Aya Kakizaki, Sadanori Furudate, Masayuki Asano, Setsuya Aiba
Format: Article
Language:English
Published: Karger Publishers 2016-02-01
Series:Case Reports in Dermatology
Subjects:
Plexiform fibrohistiocytic tumor
Periostin
Tumor-associated macrophages
Immunomodulation
Online Access:http://www.karger.com/Article/FullText/444045
id doaj-631130bb77d34938b038845e028ed04c
record_format Article
spelling doaj-631130bb77d34938b038845e028ed04c2020-11-24T23:45:21ZengKarger PublishersCase Reports in Dermatology1662-65672016-02-0181263010.1159/000444045444045Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal FactorKosuke ShidoTaku FujimuraAya KakizakiSadanori FurudateMasayuki AsanoSetsuya AibaPlexiform fibrohistiocytic tumor (PFT) is a rare mesenchymal neoplasm of intermediate malignant potential with a high local recurrence rate. In this report, we describe a case of PFT on the ear, which showed a dense deposition of periostin (POSTN) in the stromal areas of the tumor. In addition, dense infiltration of CD163+CD206- tumor-associated macrophages (TAMs) was detected in the same areas as POSTN. Since POSTN was previously reported to possess immunomodulatory effects on TAMs, our present report suggested the significance of the POSTN/TAMs axis in the progression of PFT.http://www.karger.com/Article/FullText/444045Plexiform fibrohistiocytic tumorPeriostinTumor-associated macrophagesImmunomodulation
collection DOAJ
language English
format Article
sources DOAJ
author Kosuke Shido
Taku Fujimura
Aya Kakizaki
Sadanori Furudate
Masayuki Asano
Setsuya Aiba
spellingShingle Kosuke Shido
Taku Fujimura
Aya Kakizaki
Sadanori Furudate
Masayuki Asano
Setsuya Aiba
Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor
Case Reports in Dermatology
Plexiform fibrohistiocytic tumor
Periostin
Tumor-associated macrophages
Immunomodulation
author_facet Kosuke Shido
Taku Fujimura
Aya Kakizaki
Sadanori Furudate
Masayuki Asano
Setsuya Aiba
author_sort Kosuke Shido
title Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor
title_short Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor
title_full Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor
title_fullStr Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor
title_full_unstemmed Plexiform Fibrohistiocytic Tumor on the Ear: Case Report and Immunohistochemical Investigation of Stromal Factor
title_sort plexiform fibrohistiocytic tumor on the ear: case report and immunohistochemical investigation of stromal factor
publisher Karger Publishers
series Case Reports in Dermatology
issn 1662-6567
publishDate 2016-02-01
description Plexiform fibrohistiocytic tumor (PFT) is a rare mesenchymal neoplasm of intermediate malignant potential with a high local recurrence rate. In this report, we describe a case of PFT on the ear, which showed a dense deposition of periostin (POSTN) in the stromal areas of the tumor. In addition, dense infiltration of CD163+CD206- tumor-associated macrophages (TAMs) was detected in the same areas as POSTN. Since POSTN was previously reported to possess immunomodulatory effects on TAMs, our present report suggested the significance of the POSTN/TAMs axis in the progression of PFT.
topic Plexiform fibrohistiocytic tumor
Periostin
Tumor-associated macrophages
Immunomodulation
url http://www.karger.com/Article/FullText/444045
work_keys_str_mv AT kosukeshido plexiformfibrohistiocytictumorontheearcasereportandimmunohistochemicalinvestigationofstromalfactor
AT takufujimura plexiformfibrohistiocytictumorontheearcasereportandimmunohistochemicalinvestigationofstromalfactor
AT ayakakizaki plexiformfibrohistiocytictumorontheearcasereportandimmunohistochemicalinvestigationofstromalfactor
AT sadanorifurudate plexiformfibrohistiocytictumorontheearcasereportandimmunohistochemicalinvestigationofstromalfactor
AT masayukiasano plexiformfibrohistiocytictumorontheearcasereportandimmunohistochemicalinvestigationofstromalfactor
AT setsuyaaiba plexiformfibrohistiocytictumorontheearcasereportandimmunohistochemicalinvestigationofstromalfactor
_version_ 1725496106408738816

Similar Items