LPS aggravates lung inflammation induced by RSV by promoting the ERK-MMP-12 signaling pathway in mice

LPS aggravates lung inflammation induced by RSV by promoting the ERK-MMP-12 signaling pathway in mice

Abstract Background RSV can lead to persistent airway inflammation and airway hyperresponsiveness (AHR), and is intimately associated with childhood recurrent wheezing and asthma, but the underlying mechanisms remain unclear. Lipopolysaccharide (LPS) is also implicated in the onset and exacerbation...

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Bibliographic Details
Main Authors: Shenglin Chen, Jun Xie, Keting Zhao, Luo Ren, Yu Deng, Xiaohong Xie, Shiyi Chen, Hongmei Xu, Xiaoru Long, Enmei Liu
Format: Article
Language:English
Published: BMC 2020-07-01
Series:Respiratory Research
Subjects:
RSV
LPS
MMP-12
Lung inflammation
AHR
Online Access:http://link.springer.com/article/10.1186/s12931-020-01453-6

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