A conjoined universal helper epitope can unveil antitumor effects of a neoantigen vaccine targeting an MHC class I-restricted neoepitope

A conjoined universal helper epitope can unveil antitumor effects of a neoantigen vaccine targeting an MHC class I-restricted neoepitope

Abstract Personalized cancer vaccines targeting neoantigens arising from somatic missense mutations are currently being evaluated for the treatment of various cancers due to their potential to elicit a multivalent, tumor-specific immune response. Several cancers express a low number of neoantigens;...

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Bibliographic Details
Main Authors: Adam M. Swartz, Kendra L. Congdon, Smita K. Nair, Qi-Jing Li, James E. Herndon, Carter M. Suryadevara, Katherine A. Riccione, Gary E. Archer, Pamela K. Norberg, Luis A. Sanchez-Perez, John H. Sampson
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-020-00273-5

Internet

https://doi.org/10.1038/s41541-020-00273-5

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