Fulminant Hepatic Failure in the Course of an Outpatient Anesthetic Procedure: Sevoflurane among Other High-Risk Factors

Fulminant Hepatic Failure in the Course of an Outpatient Anesthetic Procedure: Sevoflurane among Other High-Risk Factors

A 20-year-old man underwent an outpatient general anesthetic procedure with sevoflurane for the correction of a bilateral gynecomastia. The patient had been first exposed to sevoflurane two years before, without any complication. He presented an overweight with a body mass index (BMI) of 31.4 kg/m2...

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Main Authors: Céline Cheron, Perrine Hoet, Nathalie Renard, Geoffroy Vanderweerden, Cristina Miscu, Mina Komuta, Pierre-François Laterre, Philippe Hantson
Format: Article
Language:English
Published: Hindawi Limited 2020-01-01
Series:Case Reports in Anesthesiology
Online Access:http://dx.doi.org/10.1155/2020/5124098
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spelling doaj-6305eefc7dfa45178a128c33932c320a2020-11-25T02:17:10ZengHindawi LimitedCase Reports in Anesthesiology2090-63822090-63902020-01-01202010.1155/2020/51240985124098Fulminant Hepatic Failure in the Course of an Outpatient Anesthetic Procedure: Sevoflurane among Other High-Risk FactorsCéline Cheron0Perrine Hoet1Nathalie Renard2Geoffroy Vanderweerden3Cristina Miscu4Mina Komuta5Pierre-François Laterre6Philippe Hantson7Department of Intensive Care, Université Catholique de Louvain, Cliniques St-Luc, 1200 Brussels, BelgiumLouvain Centre for Toxicology and Applied Pharmacology, Université Catholique de Louvain, 1200 Brussels, BelgiumDepartment of Pathology, Centre Hospitalier de Wallonie Picarde, Tournai, BelgiumDepartment of Anesthesiology, Centre Hospitalier de Wallonie Picarde, Tournai, BelgiumDepartment of Gastroenterology, Centre Hospitalier de Wallonie Picarde, Tournai, BelgiumDepartment of Pathology, Université Catholique de Louvain, Cliniques St-Luc, 1200 Brussels, BelgiumDepartment of Intensive Care, Université Catholique de Louvain, Cliniques St-Luc, 1200 Brussels, BelgiumDepartment of Intensive Care, Université Catholique de Louvain, Cliniques St-Luc, 1200 Brussels, BelgiumA 20-year-old man underwent an outpatient general anesthetic procedure with sevoflurane for the correction of a bilateral gynecomastia. The patient had been first exposed to sevoflurane two years before, without any complication. He presented an overweight with a body mass index (BMI) of 31.4 kg/m2 and had an episode of “binge” drinking a few days before anesthesia. He became icteric from postoperative day 9, and after the worsening of liver function tests, the liver biopsy revealed centrilobular necrosis. The patient became encephalopathic and required urgent liver transplantation on postoperative day 30. The possibility of a sevoflurane-related fulminant hepatic failure is discussed.http://dx.doi.org/10.1155/2020/5124098
collection DOAJ
language English
format Article
sources DOAJ
author Céline Cheron
Perrine Hoet
Nathalie Renard
Geoffroy Vanderweerden
Cristina Miscu
Mina Komuta
Pierre-François Laterre
Philippe Hantson
spellingShingle Céline Cheron
Perrine Hoet
Nathalie Renard
Geoffroy Vanderweerden
Cristina Miscu
Mina Komuta
Pierre-François Laterre
Philippe Hantson
Fulminant Hepatic Failure in the Course of an Outpatient Anesthetic Procedure: Sevoflurane among Other High-Risk Factors
Case Reports in Anesthesiology
author_facet Céline Cheron
Perrine Hoet
Nathalie Renard
Geoffroy Vanderweerden
Cristina Miscu
Mina Komuta
Pierre-François Laterre
Philippe Hantson
author_sort Céline Cheron
title Fulminant Hepatic Failure in the Course of an Outpatient Anesthetic Procedure: Sevoflurane among Other High-Risk Factors
title_short Fulminant Hepatic Failure in the Course of an Outpatient Anesthetic Procedure: Sevoflurane among Other High-Risk Factors
title_full Fulminant Hepatic Failure in the Course of an Outpatient Anesthetic Procedure: Sevoflurane among Other High-Risk Factors
title_fullStr Fulminant Hepatic Failure in the Course of an Outpatient Anesthetic Procedure: Sevoflurane among Other High-Risk Factors
title_full_unstemmed Fulminant Hepatic Failure in the Course of an Outpatient Anesthetic Procedure: Sevoflurane among Other High-Risk Factors
title_sort fulminant hepatic failure in the course of an outpatient anesthetic procedure: sevoflurane among other high-risk factors
publisher Hindawi Limited
series Case Reports in Anesthesiology
issn 2090-6382
2090-6390
publishDate 2020-01-01
description A 20-year-old man underwent an outpatient general anesthetic procedure with sevoflurane for the correction of a bilateral gynecomastia. The patient had been first exposed to sevoflurane two years before, without any complication. He presented an overweight with a body mass index (BMI) of 31.4 kg/m2 and had an episode of “binge” drinking a few days before anesthesia. He became icteric from postoperative day 9, and after the worsening of liver function tests, the liver biopsy revealed centrilobular necrosis. The patient became encephalopathic and required urgent liver transplantation on postoperative day 30. The possibility of a sevoflurane-related fulminant hepatic failure is discussed.
url http://dx.doi.org/10.1155/2020/5124098
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