Phosphorylation of Sox2 at Threonine 116 is a Potential Marker to Identify a Subset of Breast Cancer Cells with High Tumorigenecity and Stem-Like Features

Phosphorylation of Sox2 at Threonine 116 is a Potential Marker to Identify a Subset of Breast Cancer Cells with High Tumorigenecity and Stem-Like Features

We have previously identified a novel phenotypic dichotomy in breast cancer (BC) based on the response to a SRR2 (Sox2 regulatory region 2) reporter, with reporter responsive (RR) cells being more tumorigenic/stem-like than reporter unresponsive (RU) cells. Since the expression level of Sox2 is comp...

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Bibliographic Details
Main Authors: Nidhi Gupta, Keshav Gopal, Chengsheng Wu, Abdulraheem Alshareef, Alexandra Chow, Fang Wu, Peng Wang, Xiaoxia Ye, Gilbert Bigras, Raymond Lai
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Cancers
Subjects:
breast cancer
intra-tumoral heterogeneity
Sox2
phosphorylation
immunohistochemistry
Online Access:http://www.mdpi.com/2072-6694/10/2/41

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