TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function

TPPU treatment of burned mice dampens inflammation and generation of bioactive DHET which impairs neutrophil function

Abstract Oxylipins modulate the behavior of immune cells in inflammation. Soluble epoxide hydrolase (sEH) converts anti-inflammatory epoxyeicosatrienoic acid (EET) to dihydroxyeicosatrienoic acid (DHET). An sEH-inhibitor, TPPU, has been demonstrated to ameliorate lipopolysaccharide (LPS)- and sepsis...

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Bibliographic Details
Main Authors: Christian B. Bergmann, Bruce D. Hammock, Debin Wan, Falk Gogolla, Holly Goetzman, Charles C. Caldwell, Dorothy M. Supp
Format: Article
Language:English
Published: Nature Publishing Group 2021-08-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-96014-2

Internet

https://doi.org/10.1038/s41598-021-96014-2

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