The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct Binding to the Proconvertase C3b-B

The Sand Fly Salivary Protein Lufaxin Inhibits the Early Steps of the Alternative Pathway of Complement by Direct Binding to the Proconvertase C3b-B

Saliva of the blood feeding sand fly Lutzomyia longipalpis was previously shown to inhibit the alternative pathway (AP) of the complement system. Here, we have identified Lufaxin, a protein component in saliva, as the inhibitor of the AP. Lufaxin inhibited the deposition of C3b, Bb, Properdin, C5b,...

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Bibliographic Details
Main Authors: Antonio F. Mendes-Sousa, Vladimir Fazito do Vale, Naylene C. S. Silva, Anderson B. Guimaraes-Costa, Marcos H. Pereira, Mauricio R. V. Sant’Anna, Fabiano Oliveira, Shaden Kamhawi, José M. C. Ribeiro, John F. Andersen, Jesus G. Valenzuela, Ricardo N. Araujo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Immunology
Subjects:
sand fly
saliva
Lufaxin
complement system inhibition
alternative pathway
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01065/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01065/full

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