Acquisition of Tigecycline Resistance by Carbapenem-Resistant Klebsiella pneumoniae Confers Collateral Hypersensitivity to Aminoglycosides

Acquisition of Tigecycline Resistance by Carbapenem-Resistant Klebsiella pneumoniae Confers Collateral Hypersensitivity to Aminoglycosides

Tigecycline is a last-resort antibiotic for infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). This study aimed to broaden our understanding of the acquisition of collateral hypersensitivity by CRKP, as an evolutionary trade-off of developing resistance to tigecycline. Experimen...

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Bibliographic Details
Main Authors:	Hua-le Chen, Yan Jiang, Mei-mei Li, Yao Sun, Jian-ming Cao, Cui Zhou, Xiao-xiao Zhang, Yue Qu, Tie-li Zhou
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-07-01
Series:	Frontiers in Microbiology
Subjects:	collateral sensitivity CRKP aminoglycosides tigecycline antimicrobial resistance
Online Access:	https://www.frontiersin.org/articles/10.3389/fmicb.2021.674502/full

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