Efficacy of a Selective Binder of α<sub>V</sub>β<sub>3</sub> Integrin Linked to the Tyrosine Kinase Inhibitor Sunitinib in Ovarian Carcinoma Preclinical Models

Efficacy of a Selective Binder of α<sub>V</sub>β<sub>3</sub> Integrin Linked to the Tyrosine Kinase Inhibitor Sunitinib in Ovarian Carcinoma Preclinical Models

Ovarian carcinoma, the most lethal gynecological cancer, is characterized by late diagnosis, with drug resistance limiting the efficacy of platinum-based therapy. Since some integrins are upregulated in cancer, including ovarian carcinoma, they represent a potential target for drug delivery. Recepto...

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Bibliographic Details
Main Authors: Andrea Sartori, Cristina Corno, Michelandrea De Cesare, Eugenio Scanziani, Lucia Minoli, Lucia Battistini, Franca Zanardi, Paola Perego
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Cancers
Subjects:
integrins
molecular conjugates
ovarian carcinoma
RGD ligands
RTK inhibitors
sunitinib
Online Access:https://www.mdpi.com/2072-6694/11/4/531

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