(Pro)renin receptor triggers distinct angiotensin II-independent extracellular matrix remodeling and deterioration of cardiac function.

(Pro)renin receptor triggers distinct angiotensin II-independent extracellular matrix remodeling and deterioration of cardiac function.

<h4>Background</h4>Activation of the renin-angiotensin-system (RAS) plays a key pathophysiological role in heart failure in patients with hypertension and myocardial infarction. However, the function of (pro)renin receptor ((P)RR) is not yet solved. We determined here the direct function...

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Main Authors: Anne-Mari Moilanen, Jaana Rysä, Raisa Serpi, Erja Mustonen, Zoltán Szabò, Jani Aro, Juha Näpänkangas, Olli Tenhunen, Meeri Sutinen, Tuula Salo, Heikki Ruskoaho
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22911790/?tool=EBI

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