Vascular Calcification in Chronic Kidney Disease is Induced by Bone Morphogenetic Protein-2 via a Mechanism Involving the Wnt/β-Catenin Pathway

Vascular Calcification in Chronic Kidney Disease is Induced by Bone Morphogenetic Protein-2 via a Mechanism Involving the Wnt/β-Catenin Pathway

Background: Vascular calcification (VC), in which vascular smooth muscle cells (VSMCs) undergo a phenotypic transformation into osteoblast-like cells, is one of the emergent risk factors for the accelerated atherosclerosis process characteristic of chronic kidney disease (CKD). Phosphate is an impor...

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Bibliographic Details
Main Authors: Shu Rong, Xuezhi Zhao, Xiucai Jin, Zheng Zhang, Lei Chen, Yuxian Zhu, Weijie Yuan
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2014-11-01
Series:Cellular Physiology and Biochemistry
Subjects:
Bone morphogenetic protein-2
Chronic kidney disease
Vascular calcification
Wnt/β-catenin signaling pathway
Online Access:http://www.karger.com/Article/FullText/366400

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