Amyloidosis: The Newer Discovered ALECT2 Associated with der7q add(7)

• Main Authors: Amrita Chakrabarti, Priyanka Samal, Joydeep Chakrabartty
• Format: Article
• Language: English
• Published: JCDR Research and Publications Private Limited 2016-09-01
• Series: Journal of Clinical and Diagnostic Research
• Subjects: leucocyte derived chemotaxin 2; al protein; der7q add(7); renal amyloidosis
• Online Access: https://jcdr.net/articles/PDF/8555/21705_CE[Ra]_F(P)_PF1(ASPRAK)_PFA(AK).pdf

Amyloidosis is characterized by pathological deposition of abnormal protein aggregates in various tissues, AL protein being the commonest. ALECT 2 is the newest protein described, having a predisposition to affect the kidneys, sometimes the liver and rarely other organs. We present a case of renal amyloid ALECT 2 due to leucocyte cell derived chemotaxin 2, a novel amyloidogenic protein. The patient presented with mild proteinuria, scattered plasma cells on bone marrow examination and altered kappa/lambda ratio with associated cytogenetic abnormality of der7q add(7). It is essential to correctly type this protein and differentiate it from AL during diagnosis for appropriate and effective clinical management.