Amyloidosis: The Newer Discovered ALECT2 Associated with der7q add(7)
Amyloidosis is characterized by pathological deposition of abnormal protein aggregates in various tissues, AL protein being the commonest. ALECT 2 is the newest protein described, having a predisposition to affect the kidneys, sometimes the liver and rarely other organs. We present a case of renal...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2016-09-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/8555/21705_CE[Ra]_F(P)_PF1(ASPRAK)_PFA(AK).pdf |
| Summary: | Amyloidosis is characterized by pathological deposition of abnormal protein aggregates in various tissues, AL protein being the
commonest. ALECT 2 is the newest protein described, having a predisposition to affect the kidneys, sometimes the liver and rarely
other organs. We present a case of renal amyloid ALECT 2 due to leucocyte cell derived chemotaxin 2, a novel amyloidogenic protein.
The patient presented with mild proteinuria, scattered plasma cells on bone marrow examination and altered kappa/lambda ratio
with associated cytogenetic abnormality of der7q add(7). It is essential to correctly type this protein and differentiate it from AL during
diagnosis for appropriate and effective clinical management. |
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| ISSN: | 2249-782X 0973-709X |