Two-tiered enforcement of high-fidelity DNA ligation

Two-tiered enforcement of high-fidelity DNA ligation

DNA ligases catalyze the joining of DNA strands to complete DNA replication, recombination and repair transactions. Here the authors present X-ray structures and kinetic analyses of LIG1 complexes with undamaged and oxidatively damaged DNA that unveil determinants of LIG1 substrate recognition and e...

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Bibliographic Details
Main Authors: Percy P. Tumbale, Thomas J. Jurkiw, Matthew J. Schellenberg, Amanda A. Riccio, Patrick J O’Brien, R. Scott Williams
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13478-7
Description
Summary:DNA ligases catalyze the joining of DNA strands to complete DNA replication, recombination and repair transactions. Here the authors present X-ray structures and kinetic analyses of LIG1 complexes with undamaged and oxidatively damaged DNA that unveil determinants of LIG1 substrate recognition and enzymatic fidelity.
ISSN:2041-1723

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