Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALK1 signaling in endothelial cells

Smad7 and protein phosphatase 1α are critical determinants in the duration of TGF-β/ALK1 signaling in endothelial cells

<p>Abstract</p> <p>Background</p> <p>In endothelial cells (EC), transforming growth factor-β (TGF-β) can bind to and transduce signals through ALK1 and ALK5. The TGF-β/ALK5 and TGF-β/ALK1 pathways have opposite effects on EC behaviour. Besides differential receptor bind...

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Bibliographic Details
Main Authors: Heldin Carl-Henrik, Itoh Susumu, Itoh Fumiko, Goumans Marie-José, Valdimarsdottir Gudrun, Dijke Peter
Format: Article
Language:English
Published: BMC 2006-03-01
Series:BMC Cell Biology
Online Access:http://www.biomedcentral.com/1471-2121/7/16

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