SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy.

SVIP induces localization of p97/VCP to the plasma and lysosomal membranes and regulates autophagy.

The small p97/VCP-interacting protein (SVIP) functions as an inhibitor of the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Here we show that overexpression of SVIP in HeLa cells leads to localization of p97/VCP at the plasma membrane, intracellular foci and juxtanuclear vacuoles...

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Bibliographic Details
Main Authors: Yang Wang, Petek Ballar, Yongwang Zhong, Xuebao Zhang, Chao Liu, Ying-Jiu Zhang, Mervyn J Monteiro, Jun Li, Shengyun Fang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3164199?pdf=render

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