Treprostinil alleviates hepatic mitochondrial injury during rat renal ischemia-reperfusion injury

Treprostinil alleviates hepatic mitochondrial injury during rat renal ischemia-reperfusion injury

Background: Renal ischemia-reperfusion injury (IRI) causes acute kidney injury as well as liver injury. Renal IRI depletes hepatic antioxidants, promotes hepatic inflammation and dysfunction through Tlr9 upregulation. There is no treatment available for liver injury during renal IRI. This study exam...

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Bibliographic Details
Main Authors: Joyce Hou, Evelyn Tolbert, Mark Birkenbach, Nisanne S. Ghonem
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Liver injury
Prostacyclin
Inflammation
Oxidative stress
Apoptosis
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221009562

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