Fluence Rate Differences in Photodynamic Therapy Efficacy and Activation of Epidermal Growth Factor Receptor after Treatment of the Tumor-Involved Murine Thoracic Cavity

Fluence Rate Differences in Photodynamic Therapy Efficacy and Activation of Epidermal Growth Factor Receptor after Treatment of the Tumor-Involved Murine Thoracic Cavity

Photodynamic therapy (PDT) of the thoracic cavity can be performed in conjunction with surgery to treat cancers of the lung and its pleura. However, illumination of the cavity results in tissue exposure to a broad range of fluence rates. In a murine model of intrathoracic PDT, we studied the efficac...

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Bibliographic Details
Main Authors: Craig E. Grossman, Shirron L. Carter, Julie Czupryna, Le Wang, Mary E. Putt, Theresa M. Busch
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:International Journal of Molecular Sciences
Subjects:
photodynamic therapy
fluence rate
lung
HPPH
epidermal growth factor receptor
optical imaging
proliferation
thoracic cavity
non-small cell lung carcinoma
Online Access:http://www.mdpi.com/1422-0067/17/1/101

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