Microextração em fase líquida (LPME): fundamentos da técnica e aplicações na análise de fármacos em fluidos biológicos Liquid-phase microextraction (LPME): fundamentals and applications to the analysis of drugs in biological samples

• Main Authors: Anderson Rodrigo Moraes de Oliveira, Igor Rafael dos Santos Magalhães, Fernando José Malagueño de Santana, Pierina Sueli Bonato
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2008-01-01
• Series: Química Nova
• Subjects: liquid-phase microextraction; drug analysis; biological samples
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422008000300031

<abstract language="eng">The analysis of drugs and metabolites in biological fluids usually requires extraction procedures to achieve sample clean-up and analyte preconcentration. Commonly, extraction procedures are performed using liquid-liquid extraction or solid-phase extraction. Nevertheless, these extraction techniques are considered to be time-consuming and require a large amount of organic solvents. On this basis, microextraction techniques have been developed. Among them, liquid-phase microextraction has been standing out. This review describes the liquid-phase microextraction technique based on hollow fibers as a novel and promising alternative in sample preparation prior to chromatographic or electrophoretic analysis. The basic concepts related to this technique and its applicability in extraction of drugs are discussed.