Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface

Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface

Hepatitis E virus (HEV) infection can result in severe placental disease, but mechanisms underlying pathogenicity are poorly understood. Here, the authors develop an ex vivo model for HEV infection at the maternal-fetal interface and compare pathogenicity of different HEV genotypes.

Bibliographic Details
Main Authors: Jordi Gouilly, Qian Chen, Johan Siewiera, Géraldine Cartron, Claude Levy, Martine Dubois, Reem Al-Daccak, Jacques Izopet, Nabila Jabrane-Ferrat, Hicham El Costa
Format: Article
Language:English
Published: Nature Publishing Group 2018-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-07200-2
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spelling doaj-62b57a30f9f24ff88521f9f37789bf792021-05-11T09:42:36ZengNature Publishing GroupNature Communications2041-17232018-11-019111310.1038/s41467-018-07200-2Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interfaceJordi Gouilly0Qian Chen1Johan Siewiera2Géraldine Cartron3Claude Levy4Martine Dubois5Reem Al-Daccak6Jacques Izopet7Nabila Jabrane-Ferrat8Hicham El Costa9Centre of Pathophysiology Toulouse Purpan, INSERM U1043, CNRS UMR5282, Toulouse III UniversityCentre of Pathophysiology Toulouse Purpan, INSERM U1043, CNRS UMR5282, Toulouse III UniversityUniversity of California San Francisco, School of Medicine, Laboratory of MedicineService de Gynécologie-Obstétrique, Hôpital Paule de Viguier, Centre Hospitalier UniversitaireService de Gynécologie-Obstétrique, Clinique Sarrus-TeinturiersLaboratoire de Virologie, Institute of Federative Biology, Centre Hospitalier UniversitaireINSERM UMRS976, Université Paris Diderot, Hôpital Saint-LouisCentre of Pathophysiology Toulouse Purpan, INSERM U1043, CNRS UMR5282, Toulouse III UniversityCentre of Pathophysiology Toulouse Purpan, INSERM U1043, CNRS UMR5282, Toulouse III UniversityCentre of Pathophysiology Toulouse Purpan, INSERM U1043, CNRS UMR5282, Toulouse III UniversityHepatitis E virus (HEV) infection can result in severe placental disease, but mechanisms underlying pathogenicity are poorly understood. Here, the authors develop an ex vivo model for HEV infection at the maternal-fetal interface and compare pathogenicity of different HEV genotypes.https://doi.org/10.1038/s41467-018-07200-2
collection DOAJ
language English
format Article
sources DOAJ
author Jordi Gouilly
Qian Chen
Johan Siewiera
Géraldine Cartron
Claude Levy
Martine Dubois
Reem Al-Daccak
Jacques Izopet
Nabila Jabrane-Ferrat
Hicham El Costa
spellingShingle Jordi Gouilly
Qian Chen
Johan Siewiera
Géraldine Cartron
Claude Levy
Martine Dubois
Reem Al-Daccak
Jacques Izopet
Nabila Jabrane-Ferrat
Hicham El Costa
Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface
Nature Communications
author_facet Jordi Gouilly
Qian Chen
Johan Siewiera
Géraldine Cartron
Claude Levy
Martine Dubois
Reem Al-Daccak
Jacques Izopet
Nabila Jabrane-Ferrat
Hicham El Costa
author_sort Jordi Gouilly
title Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface
title_short Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface
title_full Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface
title_fullStr Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface
title_full_unstemmed Genotype specific pathogenicity of hepatitis E virus at the human maternal-fetal interface
title_sort genotype specific pathogenicity of hepatitis e virus at the human maternal-fetal interface
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-11-01
description Hepatitis E virus (HEV) infection can result in severe placental disease, but mechanisms underlying pathogenicity are poorly understood. Here, the authors develop an ex vivo model for HEV infection at the maternal-fetal interface and compare pathogenicity of different HEV genotypes.
url https://doi.org/10.1038/s41467-018-07200-2
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