Quantitative Analysis of Survivin Protein Expression and Its Therapeutic Depletion by an Antisense Oligonucleotide in Human Lung Tumors

Quantitative Analysis of Survivin Protein Expression and Its Therapeutic Depletion by an Antisense Oligonucleotide in Human Lung Tumors

RNA-directed antisense and interference therapeutics are a promising treatment option for cancer. The demonstration of depletion of target proteins within human tumors in vivo using validated methodology will be a key to the application of this technology. Here, we present a flow cytometric-based ap...

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Bibliographic Details
Main Authors: Anna L Olsen, Joanne M Davies, Louise Medley, David Breen, Denis C Talbot, Peter J McHugh
Format: Article
Language:English
Published: Elsevier 2012-01-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
antisense therapy
lung cancer
survivin
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253116300841

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