Seizure developed after palonosetron intravenous injection during recovery from general anesthesia -A case report-

• Main Authors: Pyung-Gul Park, Hwa-Yong Shin, Hyun Kang, Yong Hun Jung, Young-Cheol Woo, Jin-Yun Kim, Gill Hoi Koo, Sun Gyoo Park, Chong Wha Baek
• Format: Article
• Language: English
• Published: Korean Society of Anesthesiologists 2012-08-01
• Series: Korean Journal of Anesthesiology
• Subjects: palonosetron; seizure; 5-htr antagonist
• Online Access: http://ekja.org/upload/pdf/kjae-63-173.pdf

Seizure associated with antiemetics is rare. We report seizure associated with a 5-HT3 receptor antagonist in a 38 years old female. The patient underwent ureterorenoscopic lithotripsy due to left upper ureter stone. After operation, the patient complained of nausea in the postanesthetic recovery unit. In order to subside symptom, the patient was administrated 5-HT3 receptor antagonist, palonosetron, 0.075 mg intravenously. Shortly after administration of that, the patient developed generalized tonic-clonic seizures. The symptom was subsided after midazolam and thiopental sodium were injected. But 40 minutes later, seizure recurred and subsided with midazolam again. The patient recovered completely without any specific sequelae.