Relationship of nutrigenomics and aging: Involvement of DNA methylation

Complex epigenetic mechanisms are involved in aging and longevity. Nutrition has a strong impact upon epigenetic processes and, therefore, holds promising roles in regulation of longevity and aging. In this review, we combine recently published information regarding nutrition and its impact on epige...

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Main Authors:	Iftikhar Alam, Farhad Ali, Falak Zeb, Ali Almajwal, Sadia Fatima, Xiaoyue Wu
Format:	Article
Language:	English
Published:	Elsevier 2019-06-01
Series:	Journal of Nutrition & Intermediary Metabolism
Online Access:	http://www.sciencedirect.com/science/article/pii/S2352385918300860

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spelling	doaj-629ef7336216435ebc9fcda35c8c332e2020-11-25T01:56:15ZengElsevierJournal of Nutrition & Intermediary Metabolism2352-38592019-06-0116Relationship of nutrigenomics and aging: Involvement of DNA methylationIftikhar Alam0Farhad Ali1Falak Zeb2Ali Almajwal3Sadia Fatima4Xiaoyue Wu5Clinical Nutrition, Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Saudi Arabia; Department of Human Nutrition and Dietetics, Bacha Khan University, Charsadda, Khyber Pakhtunkwa, Pakistan; Corresponding author. Clinical Nutrition, Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Saudi Arabia.Department of Biotechnology, Bacha Khan University, Charsadda, Khyber Pakhtunkwa, PakistanDepartment of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, China; Corresponding author. Nanjing Medical University, China.Clinical Nutrition, Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Saudi ArabiaDepartment of Biochemistry, Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, KP, PakistanDepartment of Nutrition and Food Hygiene, School of Public Health, Nanjing Medical University, ChinaComplex epigenetic mechanisms are involved in aging and longevity. Nutrition has a strong impact upon epigenetic processes and, therefore, holds promising roles in regulation of longevity and aging. In this review, we combine recently published information regarding nutrition and its impact on epigenetically mediated mechanisms involved in metabolic responses that lead to aging in a narrative way with questions and future directions at the end of each section. The paper strictly focuses on modulation of DNA methylation (DNAm) by nutrients, and its role in regulation of aging process. Understanding the mechanisms by which nutrition influences epigenome is crucial for the development of preventive and interventional strategies to increase well-being and health for a sustainable longevity. Keywords: Epigenetics, Nutrition, Aging, DNA methylationhttp://www.sciencedirect.com/science/article/pii/S2352385918300860
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Iftikhar Alam Farhad Ali Falak Zeb Ali Almajwal Sadia Fatima Xiaoyue Wu
spellingShingle	Iftikhar Alam Farhad Ali Falak Zeb Ali Almajwal Sadia Fatima Xiaoyue Wu Relationship of nutrigenomics and aging: Involvement of DNA methylation Journal of Nutrition & Intermediary Metabolism
author_facet	Iftikhar Alam Farhad Ali Falak Zeb Ali Almajwal Sadia Fatima Xiaoyue Wu
author_sort	Iftikhar Alam
title	Relationship of nutrigenomics and aging: Involvement of DNA methylation
title_short	Relationship of nutrigenomics and aging: Involvement of DNA methylation
title_full	Relationship of nutrigenomics and aging: Involvement of DNA methylation
title_fullStr	Relationship of nutrigenomics and aging: Involvement of DNA methylation
title_full_unstemmed	Relationship of nutrigenomics and aging: Involvement of DNA methylation
title_sort	relationship of nutrigenomics and aging: involvement of dna methylation
publisher	Elsevier
series	Journal of Nutrition & Intermediary Metabolism
issn	2352-3859
publishDate	2019-06-01
description	Complex epigenetic mechanisms are involved in aging and longevity. Nutrition has a strong impact upon epigenetic processes and, therefore, holds promising roles in regulation of longevity and aging. In this review, we combine recently published information regarding nutrition and its impact on epigenetically mediated mechanisms involved in metabolic responses that lead to aging in a narrative way with questions and future directions at the end of each section. The paper strictly focuses on modulation of DNA methylation (DNAm) by nutrients, and its role in regulation of aging process. Understanding the mechanisms by which nutrition influences epigenome is crucial for the development of preventive and interventional strategies to increase well-being and health for a sustainable longevity. Keywords: Epigenetics, Nutrition, Aging, DNA methylation
url	http://www.sciencedirect.com/science/article/pii/S2352385918300860
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Relationship of nutrigenomics and aging: Involvement of DNA methylation

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