The allosteric modulation of lipases and its possible biological relevance

The allosteric modulation of lipases and its possible biological relevance

<p>Abstract</p> <p>Background</p> <p>During the development of an enantioselective synthesis using the lipase from <it>Mucor miehei </it>an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a l...

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Main Authors: Wünsch Bernhard, Köhler Jens
Format: Article
Language:English
Published: BMC 2007-09-01
Series:Theoretical Biology and Medical Modelling
Online Access:http://www.tbiomed.com/content/4/1/34
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spelling doaj-62923bd6cdb34148858201942752efb02020-11-25T00:22:20ZengBMCTheoretical Biology and Medical Modelling1742-46822007-09-01413410.1186/1742-4682-4-34The allosteric modulation of lipases and its possible biological relevanceWünsch BernhardKöhler Jens<p>Abstract</p> <p>Background</p> <p>During the development of an enantioselective synthesis using the lipase from <it>Mucor miehei </it>an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a lipase changing its selectivity was shown.</p> <p>Theory</p> <p>Considering the biological relevance of the discovered regulation mechanism we developed a theory that describes the regulation of energy homeostasis and fat metabolism.</p> <p>Conclusion</p> <p>This theory represents a new approach to explain the cause of the metabolic syndrome and provides an innovative basis for further research activity.</p> http://www.tbiomed.com/content/4/1/34
collection DOAJ
language English
format Article
sources DOAJ
author Wünsch Bernhard
Köhler Jens
spellingShingle Wünsch Bernhard
Köhler Jens
The allosteric modulation of lipases and its possible biological relevance
Theoretical Biology and Medical Modelling
author_facet Wünsch Bernhard
Köhler Jens
author_sort Wünsch Bernhard
title The allosteric modulation of lipases and its possible biological relevance
title_short The allosteric modulation of lipases and its possible biological relevance
title_full The allosteric modulation of lipases and its possible biological relevance
title_fullStr The allosteric modulation of lipases and its possible biological relevance
title_full_unstemmed The allosteric modulation of lipases and its possible biological relevance
title_sort allosteric modulation of lipases and its possible biological relevance
publisher BMC
series Theoretical Biology and Medical Modelling
issn 1742-4682
publishDate 2007-09-01
description <p>Abstract</p> <p>Background</p> <p>During the development of an enantioselective synthesis using the lipase from <it>Mucor miehei </it>an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a lipase changing its selectivity was shown.</p> <p>Theory</p> <p>Considering the biological relevance of the discovered regulation mechanism we developed a theory that describes the regulation of energy homeostasis and fat metabolism.</p> <p>Conclusion</p> <p>This theory represents a new approach to explain the cause of the metabolic syndrome and provides an innovative basis for further research activity.</p>
url http://www.tbiomed.com/content/4/1/34
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