The allosteric modulation of lipases and its possible biological relevance
<p>Abstract</p> <p>Background</p> <p>During the development of an enantioselective synthesis using the lipase from <it>Mucor miehei </it>an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a l...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2007-09-01
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| Series: | Theoretical Biology and Medical Modelling |
| Online Access: | http://www.tbiomed.com/content/4/1/34 |
| Summary: | <p>Abstract</p> <p>Background</p> <p>During the development of an enantioselective synthesis using the lipase from <it>Mucor miehei </it>an unusual reaction course was observed, which was analyzed precisely. For the first time an allosteric modulation of a lipase changing its selectivity was shown.</p> <p>Theory</p> <p>Considering the biological relevance of the discovered regulation mechanism we developed a theory that describes the regulation of energy homeostasis and fat metabolism.</p> <p>Conclusion</p> <p>This theory represents a new approach to explain the cause of the metabolic syndrome and provides an innovative basis for further research activity.</p> |
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| ISSN: | 1742-4682 |