Fabrication of Chitosan Nanoparticles Containing Samarium Ion Potentially Applicable for Fluorescence Detection and Energy Transfer
Chitosan is a natural polysaccharide that has ideal properties as a polymer nanoparticle for drug delivery applications because it is easy to synthesize, inexpensive, biocompatible, biodegradable, non-immunogenic, and non-toxic. In this study, chitosan nanoparticles were fabricated in an acidic...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Universitas Indonesia
2018-12-01
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| Series: | International Journal of Technology |
| Subjects: | |
| Online Access: | http://ijtech.eng.ui.ac.id/article/view/2576 |
| Summary: | Chitosan is a natural polysaccharide that has ideal
properties as a polymer nanoparticle for drug delivery applications because it
is easy to synthesize, inexpensive, biocompatible, biodegradable,
non-immunogenic, and non-toxic. In this study, chitosan nanoparticles were
fabricated in an acidic solution in the presence of potassium persulfate using
a microwave technique. The effects of the reaction time, temperature, and
weight ratio of potassium persulfate/chitosan on the yield and particle size
were evaluated. It was found that the yield increased non-linearly, whereas the
size of chitosan nanoparticles was 3 nm in the absence of potassium persulfate,
which tended to increase with an increase in the potassium persulfate
concentration. The chitosan nanoparticles were also treated with samarium for
fluorescence detection. The fluorescence intensity at 590 nm of
samarium-treated chitosan nanoparticles increased by a factor of more than 20
when compared with the samarium ion itself and was significantly higher than
that of the untreated chitosan nanoparticles. It is indicated that chitosan
nanoparticles are not only useful for drug carriers, where the drug delivery
can be traced by monitoring fluorescence emission, but with the photoemissive
properties of chitosan nanoparticles treated with samarium, they could also be
applicable as environmentally friendly photocatalysts for the photodegradation
of discharged pollutants as well as efficient photosensitizers that participate
in energy transfer. |
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| ISSN: | 2086-9614 2087-2100 |