A thymic neuroendocrine tumour in a young female: a rare cause of relapsing and remitting Cushing’s syndrome

We present a case of a young female patient with a rare cause of relapsing and remitting Cushing’s syndrome due to ectopic ACTH secretion from a thymic neuroendocrine tumour. A 34-year-old female presented with a constellation of symptoms of Cushing’s syndrome, including facial swelling, muscle weak...

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Main Authors:	M J Trott, G Farah, V J Stokes, L M Wang, A B Grossman
Format:	Article
Language:	English
Published:	Bioscientifica 2016-05-01
Series:	Endocrinology, Diabetes & Metabolism Case Reports
Online Access:	https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-16-0018

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spelling	doaj-628c00d6212647389b5089417b483e312020-11-24T23:48:33ZengBioscientificaEndocrinology, Diabetes & Metabolism Case Reports2052-05732052-05732016-05-011510.1530/EDM-16-0018A thymic neuroendocrine tumour in a young female: a rare cause of relapsing and remitting Cushing’s syndromeM J Trott0G Farah1V J Stokes2L M Wang3A B Grossman4 Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UKDepartment of Cellular Pathology, John Radcliffe Hospital, Oxford University Hospitals NHS Trust, Oxford, UK Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UKWe present a case of a young female patient with a rare cause of relapsing and remitting Cushing’s syndrome due to ectopic ACTH secretion from a thymic neuroendocrine tumour. A 34-year-old female presented with a constellation of symptoms of Cushing’s syndrome, including facial swelling, muscle weakness and cognitive impairment. We use the terms ‘relapsing and remitting’ in this case report, given the unpredictable time course of symptoms, which led to a delay of 2 years before the correct diagnosis of hypercortisolaemia. Diagnostic workup confirmed ectopic ACTH secretion, and a thymic mass was seen on mediastinal imaging. The patient subsequently underwent thymectomy with complete resolution of her symptoms. Several case series have documented the association of Cushing’s syndrome with thymic neuroendocrine tumours (NETs), although to our knowledge there are a few published cases of patients with relapsing and remitting symptoms. This case is also notable for the absence of features of the MEN-1 syndrome, along with the female gender of our patient and her history of non-smoking.https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-16-0018
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	M J Trott G Farah V J Stokes L M Wang A B Grossman
spellingShingle	M J Trott G Farah V J Stokes L M Wang A B Grossman A thymic neuroendocrine tumour in a young female: a rare cause of relapsing and remitting Cushing’s syndrome Endocrinology, Diabetes & Metabolism Case Reports
author_facet	M J Trott G Farah V J Stokes L M Wang A B Grossman
author_sort	M J Trott
title	A thymic neuroendocrine tumour in a young female: a rare cause of relapsing and remitting Cushing’s syndrome
title_short	A thymic neuroendocrine tumour in a young female: a rare cause of relapsing and remitting Cushing’s syndrome
title_full	A thymic neuroendocrine tumour in a young female: a rare cause of relapsing and remitting Cushing’s syndrome
title_fullStr	A thymic neuroendocrine tumour in a young female: a rare cause of relapsing and remitting Cushing’s syndrome
title_full_unstemmed	A thymic neuroendocrine tumour in a young female: a rare cause of relapsing and remitting Cushing’s syndrome
title_sort	thymic neuroendocrine tumour in a young female: a rare cause of relapsing and remitting cushing’s syndrome
publisher	Bioscientifica
series	Endocrinology, Diabetes & Metabolism Case Reports
issn	2052-0573 2052-0573
publishDate	2016-05-01
description	We present a case of a young female patient with a rare cause of relapsing and remitting Cushing’s syndrome due to ectopic ACTH secretion from a thymic neuroendocrine tumour. A 34-year-old female presented with a constellation of symptoms of Cushing’s syndrome, including facial swelling, muscle weakness and cognitive impairment. We use the terms ‘relapsing and remitting’ in this case report, given the unpredictable time course of symptoms, which led to a delay of 2 years before the correct diagnosis of hypercortisolaemia. Diagnostic workup confirmed ectopic ACTH secretion, and a thymic mass was seen on mediastinal imaging. The patient subsequently underwent thymectomy with complete resolution of her symptoms. Several case series have documented the association of Cushing’s syndrome with thymic neuroendocrine tumours (NETs), although to our knowledge there are a few published cases of patients with relapsing and remitting symptoms. This case is also notable for the absence of features of the MEN-1 syndrome, along with the female gender of our patient and her history of non-smoking.
url	https://www.edmcasereports.com/articles/endocrinology-diabetes-and-metabolism-case-reports/10.1530/EDM-16-0018
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A thymic neuroendocrine tumour in a young female: a rare cause of relapsing and remitting Cushing’s syndrome

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