The Role of STAT3 in Non-Small Cell Lung Cancer

Persistent phosphorylation of signal transducer and activator of transcription 3 (STAT3) has been demonstrated in 22%~65% of non-small cell lung cancers (NSCLC). STAT3 activation is mediated by receptor tyrosine kinases, such as epidermal growth factor receptor (EGFR) and MET, cytokine receptors, s...

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Bibliographic Details
Main Authors: Daijiro Harada, Nagio Takigawa, Katsuyuki Kiura
Format: Article
Language:English
Published: MDPI AG 2014-03-01
Series:Cancers
Subjects:
Online Access:http://www.mdpi.com/2072-6694/6/2/708