Molecular, Evolutionary, and Structural Analysis of the Terminal Protein Domain of Hepatitis B Virus Polymerase, a Potential Drug Target

Molecular, Evolutionary, and Structural Analysis of the Terminal Protein Domain of Hepatitis B Virus Polymerase, a Potential Drug Target

Approximately 250 million people are living with chronic hepatitis B virus (HBV) infections, which claim nearly a million lives annually. The target of all current HBV drug therapies (except interferon) is the viral polymerase; specifically, the reverse transcriptase domain. Although no high-resolut...

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Bibliographic Details
Main Authors: Timothy S. Buhlig, Anastasia F. Bowersox, Daniel L. Braun, Desiree N. Owsley, Kortney D. James, Alfredo J. Aranda, Connor D. Kendrick, Nicole A. Skalka, Daniel N. Clark
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Viruses
Subjects:
hepatitis B virus
terminal protein
protein priming
Online Access:https://www.mdpi.com/1999-4915/12/5/570

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https://www.mdpi.com/1999-4915/12/5/570

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