Metabolic remodeling during somatic cell reprogramming to induced pluripotent stem cells: involvement of hypoxia-inducible factor 1

Metabolic remodeling during somatic cell reprogramming to induced pluripotent stem cells: involvement of hypoxia-inducible factor 1

Abstract Induced pluripotent stem cells (iPSCs) were first established from differentiated somatic cells by gene introduction of key transcription factors, OCT4, SOX2, KLF4, and c-MYC, over a decade ago. Although iPSCs can be applicable for regenerative medicine, disease modeling and drug screening,...

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Bibliographic Details
Main Authors: Tomoaki Ishida, Shu Nakao, Tomoe Ueyama, Yukihiro Harada, Teruhisa Kawamura
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Inflammation and Regeneration
Subjects:
Induced pluripotent stem cells
Reprogramming
Metabolic shift
Hypoxia-inducible factor
Regenerative medicine
Glycolysis
Online Access:http://link.springer.com/article/10.1186/s41232-020-00117-8

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http://link.springer.com/article/10.1186/s41232-020-00117-8

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