SIRT1 Mediates Melatonin’s Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence

SIRT1 Mediates Melatonin’s Effects on Microglial Activation in Hypoxia: In Vitro and In Vivo Evidence

Melatonin exerts direct neuroprotection against cerebral hypoxic damage, but the mechanisms of its action on microglia have been less characterized. Using both in vitro and in vivo models of hypoxia, we here focused on the role played by silent mating type information regulation 2 homolog 1 (SIRT1)...

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Bibliographic Details
Main Authors: Sara Merlo, Juan Pablo Luaces, Simona Federica Spampinato, Nicolas Toro-Urrego, Grazia Ilaria Caruso, Fabio D’Amico, Francisco Capani, Maria Angela Sortino
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Biomolecules
Subjects:
cobalt chloride
rat common carotid artery occlusion (ccao)
5-methoxy-<i>n</i>-acetyltryptamine
melatonin receptors
silent mating type information regulation 2 homolog 1 (sirt1)
amoeboid microglia
nuclear factor-kappa b (nf-kb)
Online Access:https://www.mdpi.com/2218-273X/10/3/364

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