Evaluation of the Interactions between Human Serum Albumin (HSA) and Non-Steroidal Anti-Inflammatory (NSAIDs) Drugs by Multiwavelength Molecular Fluorescence, Structural and Computational Analysis

Evaluation of the Interactions between Human Serum Albumin (HSA) and Non-Steroidal Anti-Inflammatory (NSAIDs) Drugs by Multiwavelength Molecular Fluorescence, Structural and Computational Analysis

The interaction between drugs and transport proteins, such as albumins, is a key factor in drug bioavailability. One of the techniques commonly used for the evaluation of the drug-protein complex formation is fluorescence. This work studies the interaction of human serum albumin (HSA) with four non-...

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Bibliographic Details
Main Authors: Susana Amézqueta, José Luís Beltrán, Anna Maria Bolioli, Lluís Campos-Vicens, Francisco Javier Luque, Clara Ràfols
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Pharmaceuticals
Subjects:
non-steroidal anti-inflammatory drugs
drug-protein interactions
human serum albumin
fluorescence multiwavelength data treatment
fluorescence quenching
molecular modeling
Online Access:https://www.mdpi.com/1424-8247/14/3/214

Internet

https://www.mdpi.com/1424-8247/14/3/214

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