The Phosphate Source Influences Gene Expression and Quality of Mineralization during In Vitro Osteogenic Differentiation of Human Mesenchymal Stem Cells.

For in vitro differentiation of bone marrow-derived mesenchymal stem cells/mesenchymal stromal cells into osteoblasts by 2-dimensional cell culture a variety of protocols have been used and evaluated in the past. Especially the external phosphate source used to induce mineralization varies considera...

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Bibliographic Details
Main Authors: Luisa M Schäck, Sandra Noack, Ramona Winkler, Gesa Wißmann, Peter Behrens, Mathias Wellmann, Michael Jagodzinski, Christian Krettek, Andrea Hoffmann
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3688813?pdf=render