Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease

BackgroundQuality of life (QoL) was worse in Parkinson’s disease patients with mild cognitive impairment (PD-MCI) or dementia (PDD) than PD patients with normal cognition (PD-NC). The aim of this study was to investigate and compare the potential heterogeneous determinants of QoL in PD patients with...

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Main Authors: Yun Fan, Xiaoniu Liang, Linlin Han, Yan Shen, Bo Shen, Chen Chen, Yimin Sun, Jian Wang, Yilin Tang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Aging Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2020.00269/full
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spelling doaj-625b8ff6518b4348b0068c144b6677422020-11-25T03:26:37ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652020-08-011210.3389/fnagi.2020.00269566042Determinants of Quality of Life According to Cognitive Status in Parkinson’s DiseaseYun FanXiaoniu LiangLinlin HanYan ShenBo ShenChen ChenYimin SunJian WangYilin TangBackgroundQuality of life (QoL) was worse in Parkinson’s disease patients with mild cognitive impairment (PD-MCI) or dementia (PDD) than PD patients with normal cognition (PD-NC). The aim of this study was to investigate and compare the potential heterogeneous determinants of QoL in PD patients with different cognitive statuses.MethodsWe recruited 600 PD patients, including 185 PD-NC patients, 336 PD-MCI patients and 79 PDD patients, in this cross-sectional study. All patients completed the QoL assessment by the 39-item Parkinson’s Disease Questionnaire (PDQ-39), as well as clinical evaluations and neuropsychological tests. The determinants of the QoL were analyzed by multiple stepwise regression analysis.ResultsQoL was more impaired across the three groups (PD-NC < PD-MCI < PDD). The Unified Parkinson’s Disease Rating Scale part III (UPDRS-III) score, Geriatric Depression Rating Scale (GDS) score and daily levodopa equivalent dose (LED) were independent variables of PDQ-39 in PD-NC patients. The GDS score, disease duration, UPDRS-III score, Epworth Sleepiness Score (ESS) and sex were independent variables of PDQ-39 in PD-MCI patients. The GDS score and disease duration were independent variables of PDQ-39 in PDD patients.ConclusionThe determinants of QoL in PD-NC, PD-MCI and PDD patients were heterogeneous. Motor function was considered to be the most crucial determinant for QoL in PD-NC, while depression was indicated to be the most vital determinant for PD-MCI and PDD. For QoL improvement, clinicians might need to focus more on motor function in PD-NC patients and on depression in PD-MCI and PDD patients.https://www.frontiersin.org/article/10.3389/fnagi.2020.00269/fullParkinson’s diseasemild cognitive impairmentdementiaquality of lifedeterminants
collection DOAJ
language English
format Article
sources DOAJ
author Yun Fan
Xiaoniu Liang
Linlin Han
Yan Shen
Bo Shen
Chen Chen
Yimin Sun
Jian Wang
Yilin Tang
spellingShingle Yun Fan
Xiaoniu Liang
Linlin Han
Yan Shen
Bo Shen
Chen Chen
Yimin Sun
Jian Wang
Yilin Tang
Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease
Frontiers in Aging Neuroscience
Parkinson’s disease
mild cognitive impairment
dementia
quality of life
determinants
author_facet Yun Fan
Xiaoniu Liang
Linlin Han
Yan Shen
Bo Shen
Chen Chen
Yimin Sun
Jian Wang
Yilin Tang
author_sort Yun Fan
title Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease
title_short Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease
title_full Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease
title_fullStr Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease
title_full_unstemmed Determinants of Quality of Life According to Cognitive Status in Parkinson’s Disease
title_sort determinants of quality of life according to cognitive status in parkinson’s disease
publisher Frontiers Media S.A.
series Frontiers in Aging Neuroscience
issn 1663-4365
publishDate 2020-08-01
description BackgroundQuality of life (QoL) was worse in Parkinson’s disease patients with mild cognitive impairment (PD-MCI) or dementia (PDD) than PD patients with normal cognition (PD-NC). The aim of this study was to investigate and compare the potential heterogeneous determinants of QoL in PD patients with different cognitive statuses.MethodsWe recruited 600 PD patients, including 185 PD-NC patients, 336 PD-MCI patients and 79 PDD patients, in this cross-sectional study. All patients completed the QoL assessment by the 39-item Parkinson’s Disease Questionnaire (PDQ-39), as well as clinical evaluations and neuropsychological tests. The determinants of the QoL were analyzed by multiple stepwise regression analysis.ResultsQoL was more impaired across the three groups (PD-NC < PD-MCI < PDD). The Unified Parkinson’s Disease Rating Scale part III (UPDRS-III) score, Geriatric Depression Rating Scale (GDS) score and daily levodopa equivalent dose (LED) were independent variables of PDQ-39 in PD-NC patients. The GDS score, disease duration, UPDRS-III score, Epworth Sleepiness Score (ESS) and sex were independent variables of PDQ-39 in PD-MCI patients. The GDS score and disease duration were independent variables of PDQ-39 in PDD patients.ConclusionThe determinants of QoL in PD-NC, PD-MCI and PDD patients were heterogeneous. Motor function was considered to be the most crucial determinant for QoL in PD-NC, while depression was indicated to be the most vital determinant for PD-MCI and PDD. For QoL improvement, clinicians might need to focus more on motor function in PD-NC patients and on depression in PD-MCI and PDD patients.
topic Parkinson’s disease
mild cognitive impairment
dementia
quality of life
determinants
url https://www.frontiersin.org/article/10.3389/fnagi.2020.00269/full
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