Visualization of Alzheimer’s Disease Related α-/β-/γ-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer

Visualization of Alzheimer’s Disease Related α-/β-/γ-Secretase Ternary Complex by Bimolecular Fluorescence Complementation Based Fluorescence Resonance Energy Transfer

The competitive ectodomain shedding of amyloid-β precursor protein (APP) by α-secretase and β-secretase, and the subsequent regulated intramembrane proteolysis by γ-secretase are the key processes in amyloid-β peptides (Aβ) generation. Previous studies indicate that secretases form binary complex an...

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Bibliographic Details
Main Authors:	Xin Wang, Gang Pei
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-11-01
Series:	Frontiers in Molecular Neuroscience
Subjects:	Alzheimer’s disease secretase amyloid precursor protein bimolecular fluorescence complementation fluorescence resonance energy transfer
Online Access:	https://www.frontiersin.org/article/10.3389/fnmol.2018.00431/full

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