Broca's region: novel organizational principles and multiple receptor mapping.

There is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of f...

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Main Authors: Katrin Amunts, Marianne Lenzen, Angela D Friederici, Axel Schleicher, Patricia Morosan, Nicola Palomero-Gallagher, Karl Zilles
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-09-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC2943440?pdf=render
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spelling doaj-62514e1513a64a359a8404f987a5bf5d2021-07-02T13:59:36ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852010-09-018910.1371/journal.pbio.1000489Broca's region: novel organizational principles and multiple receptor mapping.Katrin AmuntsMarianne LenzenAngela D FriedericiAxel SchleicherPatricia MorosanNicola Palomero-GallagherKarl ZillesKarl ZillesThere is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of functional diversity, the subdivision of Broca's region was analyzed here using a multireceptor approach. The distribution patterns of six receptor types using in vitro receptor autoradiography revealed previously unknown areas: a ventral precentral transitional cortex 6r1, dorsal and ventral areas 44d and 44v, anterior and posterior areas 45a and 45p, and areas op8 and op9 in the frontal operculum. A significant lateralization of receptors was demonstrated with respect to the cholinergic M(2) receptor, particularly in area 44v+d. We propose a new concept of the anterior language region, which elucidates the relation between premotor cortex, prefrontal cortex, and Broca's region. It offers human brain homologues to the recently described subdivision of area 45, and the segregation of the ventral premotor cortex in macaque brains. The results provide a novel structural basis of the organization of language regions in the brain.http://europepmc.org/articles/PMC2943440?pdf=render
collection DOAJ
language English
format Article
sources DOAJ
author Katrin Amunts
Marianne Lenzen
Angela D Friederici
Axel Schleicher
Patricia Morosan
Nicola Palomero-Gallagher
Karl Zilles
Karl Zilles
spellingShingle Katrin Amunts
Marianne Lenzen
Angela D Friederici
Axel Schleicher
Patricia Morosan
Nicola Palomero-Gallagher
Karl Zilles
Karl Zilles
Broca's region: novel organizational principles and multiple receptor mapping.
PLoS Biology
author_facet Katrin Amunts
Marianne Lenzen
Angela D Friederici
Axel Schleicher
Patricia Morosan
Nicola Palomero-Gallagher
Karl Zilles
Karl Zilles
author_sort Katrin Amunts
title Broca's region: novel organizational principles and multiple receptor mapping.
title_short Broca's region: novel organizational principles and multiple receptor mapping.
title_full Broca's region: novel organizational principles and multiple receptor mapping.
title_fullStr Broca's region: novel organizational principles and multiple receptor mapping.
title_full_unstemmed Broca's region: novel organizational principles and multiple receptor mapping.
title_sort broca's region: novel organizational principles and multiple receptor mapping.
publisher Public Library of Science (PLoS)
series PLoS Biology
issn 1544-9173
1545-7885
publishDate 2010-09-01
description There is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of functional diversity, the subdivision of Broca's region was analyzed here using a multireceptor approach. The distribution patterns of six receptor types using in vitro receptor autoradiography revealed previously unknown areas: a ventral precentral transitional cortex 6r1, dorsal and ventral areas 44d and 44v, anterior and posterior areas 45a and 45p, and areas op8 and op9 in the frontal operculum. A significant lateralization of receptors was demonstrated with respect to the cholinergic M(2) receptor, particularly in area 44v+d. We propose a new concept of the anterior language region, which elucidates the relation between premotor cortex, prefrontal cortex, and Broca's region. It offers human brain homologues to the recently described subdivision of area 45, and the segregation of the ventral premotor cortex in macaque brains. The results provide a novel structural basis of the organization of language regions in the brain.
url http://europepmc.org/articles/PMC2943440?pdf=render
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