Broca's region: novel organizational principles and multiple receptor mapping.
There is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of f...
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doaj-62514e1513a64a359a8404f987a5bf5d2021-07-02T13:59:36ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852010-09-018910.1371/journal.pbio.1000489Broca's region: novel organizational principles and multiple receptor mapping.Katrin AmuntsMarianne LenzenAngela D FriedericiAxel SchleicherPatricia MorosanNicola Palomero-GallagherKarl ZillesKarl ZillesThere is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of functional diversity, the subdivision of Broca's region was analyzed here using a multireceptor approach. The distribution patterns of six receptor types using in vitro receptor autoradiography revealed previously unknown areas: a ventral precentral transitional cortex 6r1, dorsal and ventral areas 44d and 44v, anterior and posterior areas 45a and 45p, and areas op8 and op9 in the frontal operculum. A significant lateralization of receptors was demonstrated with respect to the cholinergic M(2) receptor, particularly in area 44v+d. We propose a new concept of the anterior language region, which elucidates the relation between premotor cortex, prefrontal cortex, and Broca's region. It offers human brain homologues to the recently described subdivision of area 45, and the segregation of the ventral premotor cortex in macaque brains. The results provide a novel structural basis of the organization of language regions in the brain.http://europepmc.org/articles/PMC2943440?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Katrin Amunts Marianne Lenzen Angela D Friederici Axel Schleicher Patricia Morosan Nicola Palomero-Gallagher Karl Zilles Karl Zilles |
spellingShingle |
Katrin Amunts Marianne Lenzen Angela D Friederici Axel Schleicher Patricia Morosan Nicola Palomero-Gallagher Karl Zilles Karl Zilles Broca's region: novel organizational principles and multiple receptor mapping. PLoS Biology |
author_facet |
Katrin Amunts Marianne Lenzen Angela D Friederici Axel Schleicher Patricia Morosan Nicola Palomero-Gallagher Karl Zilles Karl Zilles |
author_sort |
Katrin Amunts |
title |
Broca's region: novel organizational principles and multiple receptor mapping. |
title_short |
Broca's region: novel organizational principles and multiple receptor mapping. |
title_full |
Broca's region: novel organizational principles and multiple receptor mapping. |
title_fullStr |
Broca's region: novel organizational principles and multiple receptor mapping. |
title_full_unstemmed |
Broca's region: novel organizational principles and multiple receptor mapping. |
title_sort |
broca's region: novel organizational principles and multiple receptor mapping. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS Biology |
issn |
1544-9173 1545-7885 |
publishDate |
2010-09-01 |
description |
There is a considerable contrast between the various functions assigned to Broca's region and its relatively simple subdivision into two cytoarchitectonic areas (44 and 45). Since the regional distribution of transmitter receptors in the cerebral cortex has been proven a powerful indicator of functional diversity, the subdivision of Broca's region was analyzed here using a multireceptor approach. The distribution patterns of six receptor types using in vitro receptor autoradiography revealed previously unknown areas: a ventral precentral transitional cortex 6r1, dorsal and ventral areas 44d and 44v, anterior and posterior areas 45a and 45p, and areas op8 and op9 in the frontal operculum. A significant lateralization of receptors was demonstrated with respect to the cholinergic M(2) receptor, particularly in area 44v+d. We propose a new concept of the anterior language region, which elucidates the relation between premotor cortex, prefrontal cortex, and Broca's region. It offers human brain homologues to the recently described subdivision of area 45, and the segregation of the ventral premotor cortex in macaque brains. The results provide a novel structural basis of the organization of language regions in the brain. |
url |
http://europepmc.org/articles/PMC2943440?pdf=render |
work_keys_str_mv |
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