Optimal control nodes in disease-perturbed networks as targets for combination therapy
Synergistic interactions may arise between regulators in complex molecular networks. Here, the authors develop OptiCon, a computational method for de novo identification of synergistic key regulators and investigate their potential roles as candidate targets for combination therapy.
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2019-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-10215-y |