3D Monte Carlo bone marrow dosimetry for Lu-177-PSMA therapy with guidance of non-invasive 3D localization of active bone marrow via Tc-99m-anti-granulocyte antibody SPECT/CT

3D Monte Carlo bone marrow dosimetry for Lu-177-PSMA therapy with guidance of non-invasive 3D localization of active bone marrow via Tc-99m-anti-granulocyte antibody SPECT/CT

Abstract Background The bone marrow (BM) is a main risk organ during Lu-177-PSMA ligand therapy of metastasized castration-resistant prostate cancer (mCRPC) patients. So far, BM dosimetry relies on S values, which are pre-computed for reference anatomies, simplified activity distributions, and a phy...

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Bibliographic Details
Main Authors: Astrid Gosewisch, Harun Ilhan, Sebastian Tattenberg, Andrea Mairani, Katia Parodi, Julia Brosch, Lena Kaiser, Franz Josef Gildehaus, Andrei Todica, Sibylle Ziegler, Peter Bartenstein, Guido Böning
Format: Article
Language:English
Published: SpringerOpen 2019-08-01
Series:EJNMMI Research
Subjects:
Radioligand therapy
Dosimetry
Monte Carlo
Bone marrow
mCRPC
Lutetium
Online Access:http://link.springer.com/article/10.1186/s13550-019-0548-z

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http://link.springer.com/article/10.1186/s13550-019-0548-z

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