Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines

A great deal of modern catalytic research orients around the architecturally designed bio-engineered catalysts. In this context, we have adorned Cu NPs over pectin encapsulated Fe3O4 NPs. The Cu NPs were generated following a biogenic green pathway over the core-shell type nanocomposite promoted by...

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Main Authors: Weisong Xue, Guohua Yang, Bikash Karmakar, Yi Gao
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Arabian Journal of Chemistry
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S187853522100321X
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spelling doaj-624a5be5f11b49359a2bc72534dda8fa2021-08-14T04:28:57ZengElsevierArabian Journal of Chemistry1878-53522021-09-01149103306Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell linesWeisong Xue0Guohua Yang1Bikash Karmakar2Yi Gao3Department of General Surgery, The South Brother of Fujian Province Hospital, Fuzhou, Fujian Province 350000, China; General Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province 510280, ChinaDepartment of General Surgery, The South Brother of Fujian Province Hospital, Fuzhou, Fujian Province 350000, China; Corresponding author.Department of Chemistry, Gobardanga Hindu College, 24 Parganas (North), IndiaGeneral Surgery Center, Department of Hepatobiliary Surgery II, Guangdong Provincial Research Center for Artificial Organ and Tissue Engineering, Guangzhou Clinical Research and Transformation Center for Artificial Liver, Institute of Regenerative Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong Province 510280, ChinaA great deal of modern catalytic research orients around the architecturally designed bio-engineered catalysts. In this context, we have adorned Cu NPs over pectin encapsulated Fe3O4 NPs. The Cu NPs were generated following a biogenic green pathway over the core-shell type nanocomposite promoted by Mentha Pulegium flower extract as natural reducing/stabilizing agent. The as-synthesized nanocomposite was meticulously characterized by using a wide range of physicochemical techniques like FT-IR, FESEM, TEM, EDX, elemental mapping, VSM, XRD and ICP-OES analysis. The catalyst was explored in the synthesis of diversely substituted 1H-tetrazoles via three component coupling reaction (MCR), under solvent-less conditions affording high to excellent yields. Heterogeneity of the catalyst was measured through its excellent reusability, hot-filtration test and leaching study. The nanocomposite was also explored biologically in the anticancer assays. In the cytotoxicity and anti-human colon carcinoma studies, the nanocomposite was treated to colorectal adenocarcinoma (HT-29) cell line following MTT assay. The cell viability of malignant colon cell line reduced dose-dependently in the presence of Cu/Pectin@Fe3O4 nanocomposite. IC50 values of the nanocomposite were observed to be 1450.84 μg/mL against HT-29 cell line. The outstanding results showed by the developed nanocomposite, could be highly promising in cancer management in near future.http://www.sciencedirect.com/science/article/pii/S187853522100321XPectinCu NP1-substituted tetrazolesReusableCytotoxicityAnti-colon cancer
collection DOAJ
language English
format Article
sources DOAJ
author Weisong Xue
Guohua Yang
Bikash Karmakar
Yi Gao
spellingShingle Weisong Xue
Guohua Yang
Bikash Karmakar
Yi Gao
Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines
Arabian Journal of Chemistry
Pectin
Cu NP
1-substituted tetrazoles
Reusable
Cytotoxicity
Anti-colon cancer
author_facet Weisong Xue
Guohua Yang
Bikash Karmakar
Yi Gao
author_sort Weisong Xue
title Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines
title_short Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines
title_full Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines
title_fullStr Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines
title_full_unstemmed Sustainable synthesis of Cu NPs decorated on pectin modified Fe3O4 nanocomposite: Catalytic synthesis of 1-substituted-1H-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on HT-29 cell lines
title_sort sustainable synthesis of cu nps decorated on pectin modified fe3o4 nanocomposite: catalytic synthesis of 1-substituted-1h-tetrazoles and in-vitro studies on its cytotoxicity and anti-colorectal adenocarcinoma effects on ht-29 cell lines
publisher Elsevier
series Arabian Journal of Chemistry
issn 1878-5352
publishDate 2021-09-01
description A great deal of modern catalytic research orients around the architecturally designed bio-engineered catalysts. In this context, we have adorned Cu NPs over pectin encapsulated Fe3O4 NPs. The Cu NPs were generated following a biogenic green pathway over the core-shell type nanocomposite promoted by Mentha Pulegium flower extract as natural reducing/stabilizing agent. The as-synthesized nanocomposite was meticulously characterized by using a wide range of physicochemical techniques like FT-IR, FESEM, TEM, EDX, elemental mapping, VSM, XRD and ICP-OES analysis. The catalyst was explored in the synthesis of diversely substituted 1H-tetrazoles via three component coupling reaction (MCR), under solvent-less conditions affording high to excellent yields. Heterogeneity of the catalyst was measured through its excellent reusability, hot-filtration test and leaching study. The nanocomposite was also explored biologically in the anticancer assays. In the cytotoxicity and anti-human colon carcinoma studies, the nanocomposite was treated to colorectal adenocarcinoma (HT-29) cell line following MTT assay. The cell viability of malignant colon cell line reduced dose-dependently in the presence of Cu/Pectin@Fe3O4 nanocomposite. IC50 values of the nanocomposite were observed to be 1450.84 μg/mL against HT-29 cell line. The outstanding results showed by the developed nanocomposite, could be highly promising in cancer management in near future.
topic Pectin
Cu NP
1-substituted tetrazoles
Reusable
Cytotoxicity
Anti-colon cancer
url http://www.sciencedirect.com/science/article/pii/S187853522100321X
work_keys_str_mv AT weisongxue sustainablesynthesisofcunpsdecoratedonpectinmodifiedfe3o4nanocompositecatalyticsynthesisof1substituted1htetrazolesandinvitrostudiesonitscytotoxicityandanticolorectaladenocarcinomaeffectsonht29celllines
AT guohuayang sustainablesynthesisofcunpsdecoratedonpectinmodifiedfe3o4nanocompositecatalyticsynthesisof1substituted1htetrazolesandinvitrostudiesonitscytotoxicityandanticolorectaladenocarcinomaeffectsonht29celllines
AT bikashkarmakar sustainablesynthesisofcunpsdecoratedonpectinmodifiedfe3o4nanocompositecatalyticsynthesisof1substituted1htetrazolesandinvitrostudiesonitscytotoxicityandanticolorectaladenocarcinomaeffectsonht29celllines
AT yigao sustainablesynthesisofcunpsdecoratedonpectinmodifiedfe3o4nanocompositecatalyticsynthesisof1substituted1htetrazolesandinvitrostudiesonitscytotoxicityandanticolorectaladenocarcinomaeffectsonht29celllines
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