Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity

• Main Authors: Ciocilteu Maria-Viorica, Mocanu Andreea Gabriela, Mocanu Adriana, Ducu Catalin, Nicolaescu Oana Elena, Manda Valentin Costel, Turcu-Stiolica Adina, Nicolicescu Claudiu, Melinte Razvan, Balasoiu Maria, Croitoru Octavian, Neamtu Johny
• Format: Article
• Language: English
• Published: Sciendo 2018-06-01
• Series: Acta Pharmaceutica
• Subjects: hydroxiapatite-ciprofloxacin composites; wet precipitation synthesis; in vitro release profile; antibacterial activity
• Online Access: https://doi.org/10.2478/acph-2018-0011
• ISSN: 1846-9558

The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR, XRD and DLS. Ciprofloxacin determination was accomplished by HPLC, resulting in good incorporation efficiency of the drug (18.13 %). The in vitro release study (Higuchi model C = K t1/2 and Ritger-Peppas model, C = K t0.6) showed a diffusion-controlled mechanism. The antibacterial activity showed that the bacterial growth inhibition zones were approximately equal for the synthesis composites and for the mechanical mixture on the Staphylococcus aureus germ.