Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Unstructured regions in IRE1α specify BiP-mediated destabilisation of the luminal domain dimer and repression of the UPR

Coupling of endoplasmic reticulum (ER) stress to dimerisation-dependent activation of the UPR transducer IRE1 is incompletely understood. Whilst the luminal co-chaperone ERdj4 promotes a complex between the Hsp70 BiP and IRE1’s stress-sensing luminal domain (IRE1LD) that favours the latter’s monomer...

Full description

Bibliographic Details
Main Authors:	Niko Amin-Wetzel, Lisa Neidhardt, Yahui Yan, Matthias P Mayer, David Ron
Format:	Article
Language:	English
Published:	eLife Sciences Publications Ltd 2019-12-01
Series:	eLife
Subjects:	IRE1 BiP/Grp78 endoplasmic reticulum (ER) unfolded protein response (UPR) ERdj4/DNAJB9 Chinese Hamster Ovary (CHO) cells
Online Access:	https://elifesciences.org/articles/50793

Similar Items

Calcium depletion challenges endoplasmic reticulum proteostasis by destabilising BiP-substrate complexes
by: Steffen Preissler, et al.
Published: (2020-12-01)

DNAJB11 (ERDJ3) Expression is a Novel Risk Factor for Breast Cancer Survival
by: Tolga ACUN
Published: (2020-03-01)

Noncanonical binding of BiP ATPase domain to Ire1 and Perk is dissociated by unfolded protein CH1 to initiate ER stress signaling
by: Marta Carrara, et al.
Published: (2015-02-01)

Mechanism of Hsp70 specialized interactions in protein translocation and the unfolded protein response
by: Natacha Larburu, et al.
Published: (2020-08-01)

Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker
by: Steffen Preissler, et al.
Published: (2015-10-01)

Structure and Molecular Mechanism of ER Stress Signaling by the Unfolded Protein Response Signal Activator IRE1
by: Christopher J. Adams, et al.
Published: (2019-03-01)

Data on the optimizations of expression and purification of human BiP/GRP78 protein in Escherichia coli
by: Jiao Yang, et al.
Published: (2017-02-01)

AMPylation matches BiP activity to client protein load in the endoplasmic reticulum
by: Steffen Preissler, et al.
Published: (2015-12-01)

Inadequate BiP availability defines endoplasmic reticulum stress
by: Milena Vitale, et al.
Published: (2019-03-01)

THE INFLUENCE OF HIGH TEMPERATURES ON SOME PHYSIOLOGICAL INDICES AND THE CONTENT OF HSP70, BiP, IRE1 GENES mRNA IN WHEAT LEAVES
by: Irina Nilova, et al.
Published: (2018-06-01)

Characterization of BiP Genes from Pepper (Capsicum annuum L.) and the Role of CaBiP1 in Response to Endoplasmic Reticulum and Multiple Abiotic Stresses
by: Hu Wang, et al.
Published: (2017-06-01)

CSFV Infection Up-Regulates the Unfolded Protein Response to Promote Its Replication
by: Wencheng He, et al.
Published: (2017-11-01)

Triazoloacridone C-1305 impairs XBP1 splicing by acting as a potential IRE1α endoribonuclease inhibitor
by: Sylwia Bartoszewska, et al.
Published: (2021-03-01)

Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation
by: Samuel Lara-Reyna, et al.
Published: (2019-08-01)

Pharmacological Targeting of the ER-Resident Chaperones GRP94 or Cyclophilin B Induces Secretion of IL-22 Binding Protein Isoform-1 (IL-22BPi1)
by: Paloma Gómez-Fernández, et al.
Published: (2019-05-01)

A new-age for biologic therapies: Long-term drug free therapy with BiP?
by: Adrian Matthew Shields, et al.
Published: (2012-02-01)

Unfolded Protein Response (UPR) in Survival, Dormancy, Immunosuppression, Metastasis, and Treatments of Cancer Cells
by: Sheng-Kai Hsu, et al.
Published: (2019-05-01)

Overexpression of GRP78/BiP in P-Glycoprotein-Positive L1210 Cells is Responsible for Altered Response of Cells to Tunicamycin as a Stressor of the Endoplasmic Reticulum
by: Mário Šereš, et al.
Published: (2020-04-01)

The endoplasmic reticulum chaperone ERdj4 is required for survival, glucose metabolism and B cell development
by: Fritz, Jill M.
Published: (2012)

GRP78 Overexpression Triggers PINK1-IP<sub>3</sub>R-Mediated Neuroprotective Mitophagy
by: Tatiana Leiva-Rodríguez, et al.
Published: (2021-08-01)

IRE1 Alpha/XBP1 Axis Sustains Primary Effusion Lymphoma Cell Survival by Promoting Cytokine Release and STAT3 Activation
by: Roberta Gonnella, et al.
Published: (2021-01-01)

IRE1α Activation in Bone Marrow-Derived Dendritic Cells Modulates Innate Recognition of Melanoma Cells and Favors CD8+ T Cell Priming
by: Bernardita Medel, et al.
Published: (2019-01-01)

Non-ionizing radiofrequency field induces unfolded protein response (UPR) in endoplasmic reticulum of mouse neuronal cells
by: Zhen Gao, et al.
Published: (2020-09-01)

Fate of the UPR marker protein Kar2/Bip and autophagic processes in fed-batch cultures of secretory insulin precursor producing Pichia pastoris
by: Gustavo Roth, et al.
Published: (2018-08-01)

Induction of the Endoplasmic-Reticulum-Stress Response: MicroRNA-34a Targeting of the IRE1α-Branch
by: Lena Krammes, et al.
Published: (2020-06-01)

Long Interleukin-22 Binding Protein Isoform-1 Is an Intracellular Activator of the Unfolded Protein Response
by: Paloma Gómez-Fernández, et al.
Published: (2018-12-01)

BIOINFORMATIC ANALYSIS OF A MAMMALIAN BIP GENE FOR INSERTION INTO GREEN ALGAE AND COMPARISON OF ITS POSSIBLE EFFECTS ON THE SYNTHESIS OF A MAMMALIAN ANTIBODY
by: Ghazanfar, Katrina
Published: (2004)

GRP78/BiP is Involved in Ouabain-induced Endocytosis of the Na/K-ATPase in LLC-PK1 Cells
by: Kesiry, Riad
Published: (2004)

GRP78 and endoplasmic reticulum stress in endometrial cancer
by: Luca eUlianich, et al.
Published: (2014-12-01)

Role of IRE1α/XBP-1 in Cystic Fibrosis Airway Inflammation
by: Carla M. P. Ribeiro, et al.
Published: (2017-01-01)

The Unfolded Protein Response: An Overview
by: Adam Read, et al.
Published: (2021-04-01)

New Hope for Pancreatic Ductal Adenocarcinoma Treatment Targeting Endoplasmic Reticulum Stress Response: A Systematic Review
by: Nuria Garcia-Carbonero, et al.
Published: (2018-08-01)

BipD of <i>Burkholderia pseudomallei</i>: Structure, Functions, and Detection Methods
by: Kasturi Selvam, et al.
Published: (2021-03-01)

In vitro FRET analysis of IRE1 and BiP association and dissociation upon endoplasmic reticulum stress
by: Megan C Kopp, et al.
Published: (2018-01-01)

ER Stress, UPR Activation and the Inflammatory Response to Viral Infection
by: Mara Cirone
Published: (2021-04-01)

AMPylation targets the rate-limiting step of BiP’s ATPase cycle for its functional inactivation
by: Steffen Preissler, et al.
Published: (2017-10-01)

BiP Negatively Affects Ricin Transport
by: Kirsten Sandvig, et al.
Published: (2013-05-01)

The Circulating GRP78/BiP Is a Marker of Metabolic Diseases and Atherosclerosis: Bringing Endoplasmic Reticulum Stress into the Clinical Scenario
by: Josefa Girona, et al.
Published: (2019-10-01)

Fine-Tuning ER Stress Signal Transducers to Treat Amyotrophic Lateral Sclerosis
by: Danilo B. Medinas, et al.
Published: (2017-07-01)

Activation of Host IRE1α-Dependent Signaling Axis Contributes the Intracellular Parasitism of Brucella melitensis
by: Aseem Pandey, et al.
Published: (2018-04-01)