PORCN Negatively Regulates AMPAR Function Independently of Subunit Composition and the Amino-Terminal and Carboxy-Terminal Domains of AMPARs

PORCN Negatively Regulates AMPAR Function Independently of Subunit Composition and the Amino-Terminal and Carboxy-Terminal Domains of AMPARs

Most fast excitatory synaptic transmissions in the mammalian brain are mediated by α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs), which are ligand-gated cation channels. The membrane expression level of AMPARs is largely determined by auxiliary subunits in AMPAR macromolecu...

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Bibliographic Details
Main Authors: Mengping Wei, Meng Wang, Jue Wang, Feng Su, Yangzhen Wang, Meng Sun, Shanshan Wang, Mengna Liu, Hongyi Wang, Mingyang Lu, Wei Li, Yutian Gong, Lei Yang, Chen Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
AMPA receptor
PORCN
receptor trafficking
glutamate-induced currents
protein-protein interactions
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00829/full

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