Mutant SOD1 prevents normal functional recovery through enhanced glial activation and loss of motor neuron innervation after peripheral nerve injury

Mutant SOD1 prevents normal functional recovery through enhanced glial activation and loss of motor neuron innervation after peripheral nerve injury

Background: Amyotrophic lateral sclerosis (ALS) is poorly understood with no effective therapeutics. One long entertained observation is that ALS may be precipitated focally by nerve injury. Many patients with ALS are athletes or veterans, and some have suffered nerve injuries at the site where ALS...

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Bibliographic Details
Main Authors: Sarah Schram, Donald Chuang, Greg Schmidt, Hristo Piponov, Cory Helder, James Kerns, Mark Gonzalez, Fei Song, Jeffrey A. Loeb
Format: Article
Language:English
Published: Elsevier 2019-04-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996118304753

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