Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson’s Disease

Neuroprotective and Symptomatic Effects of Cannabidiol in an Animal Model of Parkinson’s Disease

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the Substantia Nigra pars compacta, leading to classical PD motor symptoms. Current therapies are purely symptomatic and do not modify disease progression. Cannabidiol (CBD), one of the main...

Full description

Bibliographic Details
Main Authors:	Claudio Giuliano, Miriam Francavilla, Gerardo Ongari, Alessandro Petese, Cristina Ghezzi, Nora Rossini, Fabio Blandini, Silvia Cerri
Format:	Article
Language:	English
Published:	MDPI AG 2021-08-01
Series:	International Journal of Molecular Sciences
Subjects:	phytocannabinoids neuroinflammation ciliary neurotrophic factor transient receptor potential vanilloid 1 6-hydroxydopamine cannabidiol
Online Access:	https://www.mdpi.com/1422-0067/22/16/8920

Similar Items

Cannabis Contaminants Limit Pharmacological Use of Cannabidiol
by: Zackary Montoya, et al.
Published: (2020-09-01)

Phytocannabinoids: Useful Drugs for the Treatment of Obesity? Special Focus on Cannabidiol
by: Patrycja Bielawiec, et al.
Published: (2020-03-01)

From an Alternative Medicine to a New Treatment for Refractory Epilepsies: Can Cannabidiol Follow the Same Path to Treat Neuropsychiatric Disorders?
by: Rafael M. Bitencourt, et al.
Published: (2021-02-01)

From Cannabis sativa to Cannabidiol: Promising Therapeutic Candidate for the Treatment of Neurodegenerative Diseases
by: Tommaso Cassano, et al.
Published: (2020-03-01)

Adhesion molecules as potential targets for neuroprotection in a rodent model of Parkinson's disease
by: Marie-Therese Armentero, et al.
Published: (2011-09-01)

A pediatric patient with autism spectrum disorder and epilepsy using cannabinoid extracts as complementary therapy: a case report
by: Juliana Andrea Ponton, et al.
Published: (2020-09-01)

Modulation of Astrocyte Activity by Cannabidiol, a Nonpsychoactive Cannabinoid
by: Ewa Kozela, et al.
Published: (2017-07-01)

New Perspectives on the Use of Cannabis in the Treatment of Psychiatric Disorders
by: Maria Scherma, et al.
Published: (2018-10-01)

Cannabidiol and Neurodevelopmental Disorders in Children
by: Keith A. Kwan Cheung, et al.
Published: (2021-05-01)

Phytocannabinoids—A Green Approach toward Non-Alcoholic Fatty Liver Disease Treatment
by: Klaudia Berk, et al.
Published: (2021-01-01)

An Evaluation of Understudied Phytocannabinoids and Their Effects in Two Neuronal Models
by: Alex Straiker, et al.
Published: (2021-09-01)

Efficacy of Phytocannabinoids in Epilepsy Treatment: Novel Approaches and Recent Advances
by: Aaron M. Farrelly, et al.
Published: (2021-04-01)

Long-Term Continuous Cervical Spinal Cord Stimulation Exerts Neuroprotective Effects in Experimental Parkinson’s Disease
by: Ken Kuwahara, et al.
Published: (2020-06-01)

Cannabinoids in the Treatment of Epilepsy: Current Status and Future Prospects
by: Morano A, et al.
Published: (2020-02-01)

Simultaneous Quantification of 17 Cannabinoids in Cannabis Inflorescence by Liquid Chromatography-Mass Spectrometry
by: Barkla, B.J, et al.
Published: (2022)

In Vitro Model of Neuroinflammation: Efficacy of Cannabigerol, a Non-Psychoactive Cannabinoid
by: Agnese Gugliandolo, et al.
Published: (2018-07-01)

Plant-Based Cannabinoids for the Treatment of Chronic Neuropathic Pain
by: Sherelle L. Casey, et al.
Published: (2018-07-01)

Inhibition of Microglia-Derived Oxidative Stress by Ciliary Neurotrophic Factor Protects Dopamine Neurons In Vivo from MPP<sup>+</sup> Neurotoxicity
by: Jeong Yeob Baek, et al.
Published: (2018-11-01)

Can Cannabidiol Affect the Efficacy of Chemotherapy and Epigenetic Treatments in Cancer?
by: Courtney Griffiths, et al.
Published: (2021-05-01)

Cannabidiol attenuates cognitive deficits and neuroinflammation induced by early alcohol exposure in a mice model
by: Alba García-Baos, et al.
Published: (2021-09-01)

Polyphenols and Cannabidiol Modulate Transcriptional Regulation of Th1/Th2 Inflammatory Genes Related to Canine Atopic Dermatitis
by: Marcella Massimini, et al.
Published: (2021-03-01)

Could the Combination of Two Non-Psychotropic Cannabinoids Counteract Neuroinflammation? Effectiveness of Cannabidiol Associated with Cannabigerol
by: Santa Mammana, et al.
Published: (2019-11-01)

Pharmacokinetics of Cannabidiol, Cannabidiolic Acid, Δ9-Tetrahydrocannabinol, Tetrahydrocannabinolic Acid and Related Metabolites in Canine Serum After Dosing With Three Oral Forms of Hemp Extract
by: Joseph J. Wakshlag, et al.
Published: (2020-09-01)

An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol
by: Paula Morales, et al.
Published: (2017-06-01)

Epilepsy and cannabidiol - a new perspective for seizures treatment
by: Ilona Kozioł, et al.
Published: (2021-08-01)

Neuroinflammation et neuroprotection dans un modèle de maladie de Parkinson précoce (lésion à la 6-hydroxydopamine chez le rat)
by: Vetel, Steven
Published: (2018)

Disposition of Cannabidiol Metabolites in Serum and Urine from Healthy Individuals Treated with Pharmaceutical Preparations of Medical Cannabis
by: Ana Pilar Pérez-Acevedo, et al.
Published: (2020-12-01)

Antioxidative and Anti-Inflammatory Properties of Cannabidiol
by: Sinemyiz Atalay, et al.
Published: (2019-12-01)

Cannabidiol Drugs Clinical Trial Outcomes and Adverse Effects
by: Christopher S. Pauli, et al.
Published: (2020-02-01)

Cannabinoids attenuate the effects of aging upon neuroinflammation and neurogenesis
by: Yannick Marchalant, et al.
Published: (2009-05-01)

Antioxidant and Neuroprotective Effects Induced by Cannabidiol and Cannabigerol in Rat CTX-TNA2 Astrocytes and Isolated Cortexes
by: Viviana di Giacomo, et al.
Published: (2020-05-01)

Neuroprotective and Neuromodulatory Effects Induced by Cannabidiol and Cannabigerol in Rat Hypo-E22 cells and Isolated Hypothalamus
by: Viviana di Giacomo, et al.
Published: (2020-01-01)

Isolation, Purification, and Antimicrobial Characterization of Cannabidiolic Acid and Cannabidiol from <i>Cannabis sativa</i> L
by: Laura Daniela Martinenghi, et al.
Published: (2020-06-01)

CONSIDERATIONS ON THE CANNABIDIOL IN THE PSYCHOTHERAPY PROCESS OF CHILDREN WITH AUTISTIC SPECTRUM DISORDER
by: Allana Daiara Correia Oliveira, et al.
Published: (2019-12-01)

Cannabidiol Protects Dopaminergic Neurons in Mesencephalic Cultures against the Complex I Inhibitor Rotenone Via Modulation of Heme Oxygenase Activity and Bilirubin
by: Johanna Catharina Duvigneau, et al.
Published: (2020-02-01)

Reasons for using cannabidiol: a cross-sectional study of French cannabidiol users
by: Davide Fortin, et al.
Published: (2021-10-01)

Detrimental Effect of Cannabidiol on the Early Onset of Diabetic Nephropathy in Male Mice
by: Beatriz Carmona-Hidalgo, et al.
Published: (2021-08-01)

Regulatory Effects of Cannabidiol on Mitochondrial Functions: A Review
by: John Zewen Chan, et al.
Published: (2021-05-01)

Towards Better Delivery of Cannabidiol (CBD)
by: Sophie Anne Millar, et al.
Published: (2020-08-01)

Cannabidiol and Other Cannabinoids in Demyelinating Diseases
by: Carmen Navarrete, et al.
Published: (2021-03-01)

Cannot write session to /tmp/vufind_sessions/sess_k0qc2m3g92mbj4a2l76712l3jd