Similar promotion of Aβ<sub>1-42 </sub>fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms

Similar promotion of Aβ<sub>1-42 </sub>fibrillogenesis by native apolipoprotein E ε3 and ε4 isoforms

<p>Abstract</p> <p>The apolipoprotein E ε4 allele contributes to the genetic susceptibility underlying a large proportion (~40–60%) of typical, sporadic Alzheimer disease. Apolipoprotein E deficient mice made transgenic for human apolipoprotein E ε4 accumulate excess cerebral amylo...

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Bibliographic Details
Main Authors: Smith Jonathan D, LeVine Harry, Martins Ralph, Sweeney David, Gandy Sam
Format: Article
Language:English
Published: BMC 2004-08-01
Series:Journal of Neuroinflammation
Online Access:http://www.jneuroinflammation.com/content/1/1/15

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